Insulin-like Growth Factor-Binding Protein 3 and Hemoglobin Concentration in Older Persons Living in the Community Export

@article{citeulike:5999099, abstract = {Abstract\ \ A decreased hemoglobin concentration is a common clinical condition in elderly subjects, and in at least 20\% of the cases it is not possible to directly attribute the anemia to specific factors. The aim of the present study was to evaluate the relationship of different levels of insulin-like growth factor-binding protein 3 (IGFBP-3) with the blood concentration of hemoglobin in persons aged 80 years and older. Data are from a baseline evaluation of the Aging and Longevity in the Sirente Geographic Area (ilSIRENTE) study (n = 253). Analysis of covariance was used to examine the effect of different IGFBP-3 levels on hemoglobin concentration. After adjustment for potential confounding variables, which included age, sex, number of diseases, renal failure, cancer, gastric ulcer, albumin, and iron concentrations, individuals in the group with higher IGFBP-3 concentrations showed a significantly higher mean hemoglobin concentration than participants in the group with lower IGFBP-3 concentrations (13.4± 1.4 g/dL versus 12.9± 1.9 g/dL, respectively; P = .03). In conclusion, the present study has shown that a higher IGFBP-3 level is associated with a higher hemoglobin concentration among older people living in the community. This finding suggests that the growth hormone/IGF axis may play an important role in hematopoiesis, and it may be implicated in the age-related decline in hemoglobin concentration.}, author = {Landi, Francesco and Russo, Andrea and Capoluongo, Ettore and Cesari, Matteo and Liperoti, Rosa and Danese, Paola and Bernabei, Roberto and Onder, Graziano}, citeulike-article-id = {5999099}, citeulike-linkout-0 = {http://dx.doi.org/10.1532/IJH97.E0629}, citeulike-linkout-1 = {http://www.springerlink.com/content/b77458267812851r}, day = {1}, doi = {10.1532/IJH97.E0629}, journal = {International Journal of Hematology}, keywords = {anemia, growth\_hormone, hemoglobin\_concentration, ifgbp-3, longevity}, month = {May}, number = {4}, pages = {294--299}, posted-at = {2009-10-24 08:13:12}, priority = {2}, title = {Insulin-like Growth Factor-Binding Protein 3 and Hemoglobin Concentration in Older Persons Living in the Community}, url = {http://dx.doi.org/10.1532/IJH97.E0629}, volume = {85}, year = {2007} }

TY - JOUR ID - citeulike:5999099 L3 - citeulike-article-id:5999099 N2 - Abstract  A decreased hemoglobin concentration is a common clinical condition in elderly subjects, and in at least 20% of the cases it is not possible to directly attribute the anemia to specific factors. The aim of the present study was to evaluate the relationship of different levels of insulin-like growth factor-binding protein 3 (IGFBP-3) with the blood concentration of hemoglobin in persons aged 80 years and older. Data are from a baseline evaluation of the Aging and Longevity in the Sirente Geographic Area (ilSIRENTE) study (n = 253). Analysis of covariance was used to examine the effect of different IGFBP-3 levels on hemoglobin concentration. After adjustment for potential confounding variables, which included age, sex, number of diseases, renal failure, cancer, gastric ulcer, albumin, and iron concentrations, individuals in the group with higher IGFBP-3 concentrations showed a significantly higher mean hemoglobin concentration than participants in the group with lower IGFBP-3 concentrations (13.4± 1.4 g/dL versus 12.9± 1.9 g/dL, respectively; P = .03). In conclusion, the present study has shown that a higher IGFBP-3 level is associated with a higher hemoglobin concentration among older people living in the community. This finding suggests that the growth hormone/IGF axis may play an important role in hematopoiesis, and it may be implicated in the age-related decline in hemoglobin concentration. IS - 4 JF - International Journal of Hematology EP - 299 TI - Insulin-like Growth Factor-Binding Protein 3 and Hemoglobin Concentration in Older Persons Living in the Community VL - 85 SP - 294 KW - anemia KW - growth_hormone KW - hemoglobin_concentration KW - ifgbp-3 KW - longevity AU - Landi, Francesco AU - Russo, Andrea AU - Capoluongo, Ettore AU - Cesari, Matteo AU - Liperoti, Rosa AU - Danese, Paola AU - Bernabei, Roberto AU - Onder, Graziano PY - 2007/05/01/ UR - http://dx.doi.org/10.1532/IJH97.E0629 ER -