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marywaye's Tang:P [4 articles]

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	Photodynamic therapy inhibits p-glycoprotein mediated multidrug resistance via JNK activation in human hepatocellular carcinoma using the photosensitizer pheophorbide a Molecular Cancer, Vol. 8, No. 1. (31 July 2009), 56. by Patrick Tang, Dong M. Zhang, Ngoc H. Xuan, et al.Stephen Tsui, Mary Waye, Siu K. Kong, Wing P. Fong, Kwok P. Fung posted to tcm photodynamic_therapy_pdt mary_waye_publications by marywaye on 2009-09-03 03:02:35 Abstract Copy My Attachments My Copy Abstract BACKGROUND:Multidrug resistance (MDR) is frequently observed after prolonged treatment in human hepatoma with conventional anti-tumor drugs, and photodynamic therapy (PDT) is a recently suggested alternative to overcome MDR. The therapeutic potential of PDT was evaluated in a multidrug resistance (MDR) human hepatoma cell line R-HepG2 with photosensitizer pheophorbide a (Pa).RESULTS:Our results demonstrated that intracellular accumulation of Pa was not reduced by the overexpression of P-glycoprotein. Pa-based PDT (Pa-PDT) significantly inhibited the growth of R-HepG2 cells with an IC50 value of 0.6 ...
	Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. Planta medica, Vol. 72, No. 1. (January 2006), pp. 28-33. by J. Y. Chan, P. M. Tang, P. M. Hon, et al.S. W. Au, S. K. Tsui, M. M. Waye, S. K. Kong, T. C. Mak, K. P. Fung posted to liver mary_waye_publications tcm by marywaye on 2009-02-23 01:30:55 Abstract Copy My Attachments My Copy Abstract Scutellaria barbata has long been used as a Chinese medicine for the treatment of liver diseases such as hepatitis and hepatocellular carcinoma. In the present study, a bioassay-guided method was used to isolate the most active components from Scutellaria barbata. The anti-proliferative effects on human hepatoma HepG2 and Hep3B cells of each fraction at every stage of the purification were monitored. An active component, which is 97% pure by high performance liquid chromatographic analysis, was isolated. Based on nuclear magnetic resonance ...
	Pheophorbide a, an active compound isolated from Scutellaria barbata, possesses photodynamic activities by inducing apoptosis in human hepatocellular carcinoma. Cancer biology & therapy, Vol. 5, No. 9. (September 2006), pp. 1111-1116. by P. M. Tang, J. Y. Chan, S. W. Au, et al.S. K. Kong, S. K. Tsui, M. M. Waye, T. C. Mak, W. P. Fong, K. P. Fung posted to liver mary_waye_publications tcm by marywaye on 2009-02-23 01:29:21 Abstract Copy My Attachments My Copy Abstract Photodynamic therapy (PDT) is an effective treatment for cancer by inducing apoptosis or necrosis in the target cells. Pheophorbide a (Pa), a chlorophyll derivative, is a photosensitzier which can induce significant anti-proliferative effects in a number of human cancer cell lines. This study investigated the action mechanism of Pa-mediated photodynamic therapy (Pa-PDT) on the human hepatocellular carcinoma, Hep3B cells. Pa-PDT significantly inhibited the growth of Hep3B cells with an IC50 value of 1.5 microM. Intracellular ROS level was increased in Pa-PDT ...
	Pheophorbide a, an active component in Scutellaria barbata, reverses P-glycoprotein-mediated multidrug resistance on a human hepatoma cell line R-HepG2. Cancer biology & therapy, Vol. 6, No. 4. (April 2007), pp. 504-509. by P. M. Tang, J. Y. Chan, D. M. Zhang, et al.S. W. Au, W. P. Fong, S. K. Kong, S. K. Tsui, M. M. Waye, T. C. Mak, K. P. Fung posted to liver mary_waye_publications tcm by marywaye on 2009-02-23 01:28:53 Abstract Copy My Attachments My Copy Abstract Scutellaria barbata, a Traditional Chinese Medicine native in southern China, has been widely used for treating liver diseases. In this study, the anti-proliferative effect of Pheophorbide a (Pa), an active component from S. barbata, was examined on a multi-drug resistant (MDR) human hepatoma cell line R-HepG2. Our study showed that Pa could significantly inhibit the growth of R-HepG2 cells with an IC50 value at 25.0 microM after 48 hours treatment. When compared with the parental HepG2 cells, Pa showed weak resistance ...

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