Gibbs tracking: A novel approach for the reconstruction of neuronal pathways Export

@article{citeulike:3349244, abstract = {Reconstruction of neuronal fibers using diffusion-weighted (DW) MRI is an emerging method in biomedical research. Existing fiber-tracking algorithms are commonly based on the ldquowalker principle.rdquo Fibers are reconstructed as trajectories of ldquowalkers,rdquo which are guided according to local diffusion properties. In this study, a new method of fiber tracking is proposed that does not engage any ldquowalkingrdquo algorithm. It resolves a number of inherent problems of the ldquowalkingrdquo approach, in particular the reconstruction of crossing and spreading fibers. In the proposed method, the fibers are built with small line elements. Each line element contributes an anisotropic term to the simulated DW signal, which is adjusted to the measured signal. This method demonstrates good results for simulated fibers. A single in vivo result demonstrates the successful reconstruction of the dominant neuronal pathways. A comparison with the diffusion tensor imaging (DTI)-based fiber assignment with continuous tracking (FACT) method and the probabilistic index of connectivity (PICo) method based on a multitensor model is performed for the callosal fibers. The result shows a strong increase in the number of reconstructed fibers. These almost fill the total white matter (WM) volume and connect a large area of the cortex. The method is very computationally expensive. Possible ways to address this problem are discussed. Magn Reson Med 60:953-963, 2008. {\copyright} 2008 Wiley-Liss, Inc.}, address = {Medical Physics, Department of Diagnostic Radiology, University Hospital, Freiburg, Germany; Section of Neuroradiology, Neurocenter, University Hospital, Freiburg, Germany; Freiburg Brain Imaging Center, Department of Neurology, University Hospital, Freiburg, Germany}, author = {Kreher, B. W. and Mader, I. and Kiselev, V. G.}, citeulike-article-id = {3349244}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mrm.21749}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121420992/ABSTRACT}, doi = {10.1002/mrm.21749}, journal = {Magnetic Resonance in Medicine}, keywords = {2008, dti, kiselev, mrm}, number = {4}, pages = {953--963}, posted-at = {2008-09-28 23:00:48}, priority = {4}, title = {Gibbs tracking: A novel approach for the reconstruction of neuronal pathways}, url = {http://dx.doi.org/10.1002/mrm.21749}, volume = {60}, year = {2008} }

TY - JOUR ID - citeulike:3349244 L3 - citeulike-article-id:3349244 N2 - Reconstruction of neuronal fibers using diffusion-weighted (DW) MRI is an emerging method in biomedical research. Existing fiber-tracking algorithms are commonly based on the ldquowalker principle.rdquo Fibers are reconstructed as trajectories of ldquowalkers,rdquo which are guided according to local diffusion properties. In this study, a new method of fiber tracking is proposed that does not engage any ldquowalkingrdquo algorithm. It resolves a number of inherent problems of the ldquowalkingrdquo approach, in particular the reconstruction of crossing and spreading fibers. In the proposed method, the fibers are built with small line elements. Each line element contributes an anisotropic term to the simulated DW signal, which is adjusted to the measured signal. This method demonstrates good results for simulated fibers. A single in vivo result demonstrates the successful reconstruction of the dominant neuronal pathways. A comparison with the diffusion tensor imaging (DTI)-based fiber assignment with continuous tracking (FACT) method and the probabilistic index of connectivity (PICo) method based on a multitensor model is performed for the callosal fibers. The result shows a strong increase in the number of reconstructed fibers. These almost fill the total white matter (WM) volume and connect a large area of the cortex. The method is very computationally expensive. Possible ways to address this problem are discussed. Magn Reson Med 60:953-963, 2008. © 2008 Wiley-Liss, Inc. IS - 4 JF - Magnetic Resonance in Medicine AD - Medical Physics, Department of Diagnostic Radiology, University Hospital, Freiburg, Germany; Section of Neuroradiology, Neurocenter, University Hospital, Freiburg, Germany; Freiburg Brain Imaging Center, Department of Neurology, University Hospital, Freiburg, Germany EP - 963 TI - Gibbs tracking: A novel approach for the reconstruction of neuronal pathways VL - 60 SP - 953 KW - 2008 KW - dti KW - kiselev KW - mrm AU - Kreher, BW AU - Mader, I AU - Kiselev, VG PY - 2008/// UR - http://dx.doi.org/10.1002/mrm.21749 ER -