Chapter 12 Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes Export

@inbook{citeulike:2405928, abstract = {Sequence conservation has traditionally been used as a means to target functional regions of complex genomes. In addition to its use in identifying coding regions of genes, the recent availability of whole genome data for a number of vertebrates has permitted high-resolution analyses of the noncoding ” dark matter” of the genome. This has resulted in the identification of a large number of highly conserved sequence elements that appear to be preserved in all bony vertebrates. Further positional analysis of these conserved noncoding elements (CNEs) in the genome demonstrates that they cluster around genes involved in developmental regulation. This chapter describes the identification and characterization of these elements, with particular reference to their composition and organization.}, author = {Woolfe, A. and Elgar, G.}, booktitle = {Long-Range Control of Gene Expression}, citeulike-article-id = {2405928}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0065-2660(07)00012-0}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0065266007000120}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18282512}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18282512}, doi = {10.1016/S0065-2660(07)00012-0}, issn = {00652660}, journal = {Adv Genet}, keywords = {cns, cns-enhancer, inter-cns-distances}, pages = {307--338}, posted-at = {2008-02-21 10:40:57}, priority = {2}, series = {Advances in Genetics}, title = {Chapter 12 Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes}, url = {http://dx.doi.org/10.1016/S0065-2660(07)00012-0}, volume = {61}, year = {2008} }

TY - CHAP ID - citeulike:2405928 L3 - citeulike-article-id:2405928 N2 - Sequence conservation has traditionally been used as a means to target functional regions of complex genomes. In addition to its use in identifying coding regions of genes, the recent availability of whole genome data for a number of vertebrates has permitted high-resolution analyses of the noncoding “dark matter” of the genome. This has resulted in the identification of a large number of highly conserved sequence elements that appear to be preserved in all bony vertebrates. Further positional analysis of these conserved noncoding elements (CNEs) in the genome demonstrates that they cluster around genes involved in developmental regulation. This chapter describes the identification and characterization of these elements, with particular reference to their composition and organization. JF - Adv Genet SE - Advances in Genetics SN - 00652660 EP - 338 TI - Chapter 12 Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes VL - 61 T2 - Long-Range Control of Gene Expression SP - 307 KW - cns KW - cns-enhancer KW - inter-cns-distances AU - Woolfe, A AU - Elgar, G PY - 2008/// UR - http://dx.doi.org/10.1016/S0065-2660(07)00012-0 ER -