Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site Export

@article{citeulike:2900118, abstract = {Foxa2 is a critical transcription factor that controls liver development and plays an important role in hepatic gluconeogensis in adult mice. Here, we use genome-wide location analysis for Foxa2 to identify its targets in the adult liver. We then show by computational analyses that Foxa2 containing cis-regulatory modules are not constructed from a random assortment of binding sites for other transcription factors expressed in the liver, but rather that their composition depends on the strength of the Foxa2 consensus site present. Genes containing a cis-regulatory module with a medium or weak Foxa2 consensus site are much more liver-specific than the genes with a strong consensus site. We not only provide a better understanding of the mechanisms of Foxa2 regulation but also introduce a novel method for identification of different cis-regulatory modules involving a single factor. 10.1093/nar/gkn366}, author = {Tuteja, Geetu and Jensen, Shane T. and White, Peter and Kaestner, Klaus H.}, citeulike-article-id = {2900118}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/nar/gkn366}, citeulike-linkout-1 = {http://nar.oxfordjournals.org/cgi/content/abstract/36/12/4149}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18556755}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18556755}, day = {1}, doi = {10.1093/nar/gkn366}, journal = {Nucl. Acids Res.}, keywords = {cns-ranking, strengthofmatch}, month = {July}, number = {12}, pages = {4149--4157}, posted-at = {2008-06-16 23:32:27}, priority = {2}, title = {Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site}, url = {http://dx.doi.org/10.1093/nar/gkn366}, volume = {36}, year = {2008} }

TY - JOUR ID - citeulike:2900118 L3 - citeulike-article-id:2900118 N2 - Foxa2 is a critical transcription factor that controls liver development and plays an important role in hepatic gluconeogensis in adult mice. Here, we use genome-wide location analysis for Foxa2 to identify its targets in the adult liver. We then show by computational analyses that Foxa2 containing cis-regulatory modules are not constructed from a random assortment of binding sites for other transcription factors expressed in the liver, but rather that their composition depends on the strength of the Foxa2 consensus site present. Genes containing a cis-regulatory module with a medium or weak Foxa2 consensus site are much more liver-specific than the genes with a strong consensus site. We not only provide a better understanding of the mechanisms of Foxa2 regulation but also introduce a novel method for identification of different cis-regulatory modules involving a single factor. 10.1093/nar/gkn366 IS - 12 JF - Nucl. Acids Res. EP - 4157 TI - Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site VL - 36 SP - 4149 KW - cns-ranking KW - strengthofmatch AU - Tuteja, Geetu AU - Jensen, Shane AU - White, Peter AU - Kaestner, Klaus PY - 2008/07/01/ UR - http://dx.doi.org/10.1093/nar/gkn366 ER -