Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints. Export

@article{citeulike:4386396, abstract = {Sequence analysis of epsilon and gamma genes and encoded globins and high-pressure liquid chromatography analysis of globin compositions in blood hemolysates obtained from embryos, fetuses and adults show that the prosimian primate Galago crassicaudatus expresses its epsilon and gamma genes only embryonically. Since rabbit, mouse and galago all have embryonic gamma genes but simian primates have fetal gamma genes, we conclude that gamma E evolved into gamma F in stem-simians. An elevated non-synonymous substitution rate characterizes this transition. The alignment of epsilon and gamma nucleotide sequences and the parsimoniously reconstructed evolutionary history of these sequences identify several anciently conserved cis-regulatory elements (phylogenetic footprints) important for gamma expression in primates and also cis-mutations which may have been involved in the recruitment of the gamma gene to a fetal program in simian primates.}, author = {Tagle, D. A. and Koop, B. F. and Goodman, M. and Slightom, J. L. and Hess, D. L. and Jones, R. T.}, citeulike-article-id = {4386396}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/3199442}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=3199442}, day = {20}, issn = {0022-2836}, journal = {Journal of molecular biology}, keywords = {comparative, conserved, footprinting}, month = {September}, number = {2}, pages = {439--455}, posted-at = {2009-04-23 14:08:28}, priority = {2}, title = {Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/3199442}, volume = {203}, year = {1988} }

TY - JOUR ID - citeulike:4386396 L3 - citeulike-article-id:4386396 N2 - Sequence analysis of epsilon and gamma genes and encoded globins and high-pressure liquid chromatography analysis of globin compositions in blood hemolysates obtained from embryos, fetuses and adults show that the prosimian primate Galago crassicaudatus expresses its epsilon and gamma genes only embryonically. Since rabbit, mouse and galago all have embryonic gamma genes but simian primates have fetal gamma genes, we conclude that gamma E evolved into gamma F in stem-simians. An elevated non-synonymous substitution rate characterizes this transition. The alignment of epsilon and gamma nucleotide sequences and the parsimoniously reconstructed evolutionary history of these sequences identify several anciently conserved cis-regulatory elements (phylogenetic footprints) important for gamma expression in primates and also cis-mutations which may have been involved in the recruitment of the gamma gene to a fetal program in simian primates. IS - 2 JF - Journal of molecular biology SN - 0022-2836 EP - 455 TI - Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints. VL - 203 SP - 439 KW - comparative KW - conserved KW - footprinting AU - Tagle, DA AU - Koop, BF AU - Goodman, M AU - Slightom, JL AU - Hess, DL AU - Jones, RT PY - 1988/09/20/ UR - http://view.ncbi.nlm.nih.gov/pubmed/3199442 ER -