Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. Export

@article{citeulike:6060578, abstract = {The characterisation of interspecies differences in gene regulation is crucial to understanding the molecular basis of phenotypic diversity and evolution. The atonal homologue Atoh7 participates in the ontogenesis of the vertebrate retina. Our study reveals how evolutionarily conserved, non-coding DNA sequences mediate both the conserved and the species-specific transcriptional features of the Atoh7 gene. In the mouse and chick retina, species-related variations in the chromatin-binding profiles of bHLH transcription factors correlate with distinct features of the Atoh7 promoters and underlie variations in the transcriptional rates of the Atoh7 genes. The different expression kinetics of the Atoh7 genes generate differences in the expression patterns of a set of genes that are regulated by Atoh7 in a dose-dependent manner, including those involved in neurite outgrowth and growth cone migration. In summary, we show how highly conserved regulatory elements are put to use in mediating non-conserved functions and creating interspecies neuronal diversity.}, author = {Skowronska-Krawczyk, Dorota and Chiodini, Florence and Ebeling, Martin and Alliod, Christine and Kundzewicz, Adam and Castro, Diogo and Ballivet, Marc and Guillemot, Fran\c{c}ois and Matter-Sadzinski, Lidia and Matter, Jean-Marc M.}, citeulike-article-id = {6060578}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/dev.033449}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19855019}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19855019}, doi = {10.1242/dev.033449}, issn = {1477-9129}, journal = {Development (Cambridge, England)}, keywords = {cns-differences, notconserved, notconservedfunction}, month = {November}, number = {22}, pages = {3767--3777}, posted-at = {2009-11-03 15:57:07}, priority = {2}, title = {Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis.}, url = {http://dx.doi.org/10.1242/dev.033449}, volume = {136}, year = {2009} }

TY - JOUR ID - citeulike:6060578 L3 - citeulike-article-id:6060578 N2 - The characterisation of interspecies differences in gene regulation is crucial to understanding the molecular basis of phenotypic diversity and evolution. The atonal homologue Atoh7 participates in the ontogenesis of the vertebrate retina. Our study reveals how evolutionarily conserved, non-coding DNA sequences mediate both the conserved and the species-specific transcriptional features of the Atoh7 gene. In the mouse and chick retina, species-related variations in the chromatin-binding profiles of bHLH transcription factors correlate with distinct features of the Atoh7 promoters and underlie variations in the transcriptional rates of the Atoh7 genes. The different expression kinetics of the Atoh7 genes generate differences in the expression patterns of a set of genes that are regulated by Atoh7 in a dose-dependent manner, including those involved in neurite outgrowth and growth cone migration. In summary, we show how highly conserved regulatory elements are put to use in mediating non-conserved functions and creating interspecies neuronal diversity. IS - 22 JF - Development (Cambridge, England) SN - 1477-9129 EP - 3777 TI - Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis. VL - 136 SP - 3767 KW - cns-differences KW - notconserved KW - notconservedfunction AU - Skowronska-Krawczyk, Dorota AU - Chiodini, Florence AU - Ebeling, Martin AU - Alliod, Christine AU - Kundzewicz, Adam AU - Castro, Diogo AU - Ballivet, Marc AU - Guillemot, François AU - Matter-Sadzinski, Lidia AU - Matter, Jean-Marc PY - 2009/11// UR - http://dx.doi.org/10.1242/dev.033449 ER -