Factor B and the Mitochondrial ATP Synthase Complex Export

@article{citeulike:5911002, abstract = {10.1074/jbc.M111256200 Factor B is a subunit of the mammalian ATP synthase complex, whose existence has been controversial. This paper describes the molecular and functional properties of a recombinant human factor B, which when added to bovine submitochondrial particles depleted of their factor B restores the energy coupling activity of the ATP synthase complexes. The mature human factor B has 175 amino acids and a molecular mass of 20,341 Da. The preparation is water-soluble, monomeric, and is inactivated by monothiol- and especially dithiol-modifying reagents, probably reacting at its cysteine residues Cys-92 and Cys-94. A likely factor B gene composed of 5 exons has been identified on chromosome 14q21.3, and the functional role of factor B in the mammalian ATP synthase complex has been discussed.}, author = {Belogrudov, Grigory I. and Hatefi, Youssef}, citeulike-article-id = {5911002}, citeulike-linkout-0 = {http://dx.doi.org/10.1074/jbc.M111256200}, citeulike-linkout-1 = {http://www.jbc.org/content/277/8/6097.abstract}, citeulike-linkout-2 = {http://www.jbc.org/content/277/8/6097.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/11744738}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=11744738}, day = {22}, doi = {10.1074/jbc.M111256200}, journal = {Journal of Biological Chemistry}, keywords = {apt, complex, mito, synthase}, month = {February}, number = {8}, pages = {6097--6103}, posted-at = {2009-10-08 19:28:44}, priority = {3}, title = {Factor B and the Mitochondrial ATP Synthase Complex}, url = {http://dx.doi.org/10.1074/jbc.M111256200}, volume = {277}, year = {2002} }

TY - JOUR ID - citeulike:5911002 L3 - citeulike-article-id:5911002 N2 - 10.1074/jbc.M111256200 Factor B is a subunit of the mammalian ATP synthase complex, whose existence has been controversial. This paper describes the molecular and functional properties of a recombinant human factor B, which when added to bovine submitochondrial particles depleted of their factor B restores the energy coupling activity of the ATP synthase complexes. The mature human factor B has 175 amino acids and a molecular mass of 20,341 Da. The preparation is water-soluble, monomeric, and is inactivated by monothiol- and especially dithiol-modifying reagents, probably reacting at its cysteine residues Cys-92 and Cys-94. A likely factor B gene composed of 5 exons has been identified on chromosome 14q21.3, and the functional role of factor B in the mammalian ATP synthase complex has been discussed. IS - 8 JF - Journal of Biological Chemistry EP - 6103 TI - Factor B and the Mitochondrial ATP Synthase Complex VL - 277 SP - 6097 KW - apt KW - complex KW - mito KW - synthase AU - Belogrudov, Grigory AU - Hatefi, Youssef PY - 2002/02/22/ UR - http://dx.doi.org/10.1074/jbc.M111256200 ER -