Telomere-associated endonuclease-deficient Penelope-like retroelements in diverse eukaryotes Export

@article{citeulike:1390023, abstract = {10.1073/pnas.0702741104 The evolutionary origin of telomerases, enzymes that maintain the ends of linear chromosomes in most eukaryotes, is a subject of debate. -like elements (PLEs) are a recently described class of eukaryotic retroelements characterized by a GIY-YIG endonuclease domain and by a reverse transcriptase domain with similarity to telomerases and group II introns. Here we report that a subset of PLEs found in bdelloid rotifers, basidiomycete fungi, stramenopiles, and plants, representing four different eukaryotic kingdoms, lack the endonuclease domain and are located at telomeres. The 5\^{a}€² truncated ends of these elements are telomere-oriented and typically capped by species-specific telomeric repeats. Most of them also carry several shorter stretches of telomeric repeats at or near their 3\^{a}€² ends, which could facilitate utilization of the telomeric G-rich 3\^{a}€² overhangs to prime reverse transcription. Many of these telomere-associated PLEs occupy a basal phylogenetic position close to the point of divergence from the telomerase-PLE common ancestor and may descend from the missing link between early eukaryotic retroelements and present-day telomerases.}, author = {Gladyshev, Eugene A. and Arkhipova, Irina R.}, citeulike-article-id = {1390023}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0702741104}, citeulike-linkout-1 = {http://www.pnas.org/content/104/22/9352.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/104/22/9352.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/104/22/9352}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/17483479}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=17483479}, day = {29}, doi = {10.1073/pnas.0702741104}, journal = {Proceedings of the National Academy of Sciences}, month = {May}, number = {22}, pages = {9352--9357}, posted-at = {2007-06-14 14:48:51}, priority = {2}, title = {Telomere-associated endonuclease-deficient Penelope-like retroelements in diverse eukaryotes}, url = {http://dx.doi.org/10.1073/pnas.0702741104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:1390023 L3 - citeulike-article-id:1390023 N2 - 10.1073/pnas.0702741104 The evolutionary origin of telomerases, enzymes that maintain the ends of linear chromosomes in most eukaryotes, is a subject of debate. -like elements (PLEs) are a recently described class of eukaryotic retroelements characterized by a GIY-YIG endonuclease domain and by a reverse transcriptase domain with similarity to telomerases and group II introns. Here we report that a subset of PLEs found in bdelloid rotifers, basidiomycete fungi, stramenopiles, and plants, representing four different eukaryotic kingdoms, lack the endonuclease domain and are located at telomeres. The 5′ truncated ends of these elements are telomere-oriented and typically capped by species-specific telomeric repeats. Most of them also carry several shorter stretches of telomeric repeats at or near their 3′ ends, which could facilitate utilization of the telomeric G-rich 3′ overhangs to prime reverse transcription. Many of these telomere-associated PLEs occupy a basal phylogenetic position close to the point of divergence from the telomerase-PLE common ancestor and may descend from the missing link between early eukaryotic retroelements and present-day telomerases. IS - 22 JF - Proceedings of the National Academy of Sciences EP - 9357 TI - Telomere-associated endonuclease-deficient Penelope-like retroelements in diverse eukaryotes VL - 104 SP - 9352 AU - Gladyshev, Eugene AU - Arkhipova, Irina PY - 2007/05/29/ UR - http://dx.doi.org/10.1073/pnas.0702741104 ER -