Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering

@article{citeulike:2813764, abstract = {Ceramic composites and scaffolds are popular implant materials in the field of dentistry, orthopedics and plastic surgery. For bone tissue engineering especially CaP-ceramics or cements and bioactive glass are suitable implant materials due to their osteoconductive properties. In this review the applicability of these ceramics but also of ceramic/polymer composites for bone tissue engineering is discussed, and in particular their use as drug delivery systems. Overall, the high density and slow biodegradability of ceramics is not beneficial for tissue engineering purposes. To address these issues, macroporosity can be introduced often in combination with osteoinductive growth factors and cells. Ceramics are good carriers for drugs, in which release patterns are strongly dependent on the chemical consistancy of the ceramic, type of drug and drug loading. Biodegradable polymers like polylactic acid, gelatin or chitosan are used as matrices for ceramic particles or as adjuvant to calcium phosphate cements. The use of these polymers can introduce a tailored biodegradation/drug release to the ceramic material.}, author = {Habraken, W. J. E. M. and Wolke, J. G. C. and Jansen, J. A. }, booktitle = {Matrices and Scaffolds for Drug Delivery in Tissue Engineering}, citeulike-article-id = {2813764}, doi = {http://dx.doi.org/10.1016/j.addr.2007.03.011}, journal = {Advanced Drug Delivery Reviews}, keywords = {bone, composites, review}, month = {May}, number = {4-5}, pages = {234--248}, posted-at = {2008-05-19 18:55:44}, priority = {3}, title = {Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering}, url = {http://dx.doi.org/10.1016/j.addr.2007.03.011}, volume = {59}, year = {2007} }

TY - JOUR ID - citeulike:2813764 L3 - citeulike-article-id:2813764 TI - Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering T2 - Matrices and Scaffolds for Drug Delivery in Tissue Engineering JF - Advanced Drug Delivery Reviews VL - 59 IS - 4-5 SP - 234 EP - 248 N2 - Ceramic composites and scaffolds are popular implant materials in the field of dentistry, orthopedics and plastic surgery. For bone tissue engineering especially CaP-ceramics or cements and bioactive glass are suitable implant materials due to their osteoconductive properties. In this review the applicability of these ceramics but also of ceramic/polymer composites for bone tissue engineering is discussed, and in particular their use as drug delivery systems. Overall, the high density and slow biodegradability of ceramics is not beneficial for tissue engineering purposes. To address these issues, macroporosity can be introduced often in combination with osteoinductive growth factors and cells. Ceramics are good carriers for drugs, in which release patterns are strongly dependent on the chemical consistancy of the ceramic, type of drug and drug loading. Biodegradable polymers like polylactic acid, gelatin or chitosan are used as matrices for ceramic particles or as adjuvant to calcium phosphate cements. The use of these polymers can introduce a tailored biodegradation/drug release to the ceramic material. KW - bone KW - composites KW - review AU - Habraken, WJEM AU - Wolke, JGC AU - Jansen, JA PY - 2007/05/30/ UR - http://dx.doi.org/10.1016/j.addr.2007.03.011 ER -