Codon Bias and Mutability in HIV Sequences Export

@article{citeulike:1696842, abstract = {Abstract.\ \  A survey of the patterns of synonymous codon preference in the HIV env gene reveals a correlation between the codon bias and the mutability requirements of different regions of the protein. At hypervariable regions in gp120 one finds a greater proportion of codons that tend to mutate nonsynonymously, but to a target that is similar in hydrophobicity and volume. We argue that this strategy results from a compromise between the selective pressure placed on the virus by the induced immune response, which favors amino acid substitutions in the complementarity determining regions, and the negative selection against missense mutations that violate structural constraints of the env protein.}, author = {Stephens, C. R. and Waelbroeck, H.}, citeulike-article-id = {1696842}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/PL00006483}, day = {5}, doi = {10.1007/PL00006483}, journal = {Journal of Molecular Evolution}, keywords = {bias, biology, codon, evolution, genetics, sequences}, month = {April}, number = {4}, pages = {390--397}, posted-at = {2007-09-26 11:26:02}, priority = {3}, title = {Codon Bias and Mutability in HIV Sequences}, url = {http://dx.doi.org/10.1007/PL00006483}, volume = {48}, year = {1999} }

TY - JOUR ID - citeulike:1696842 L3 - citeulike-article-id:1696842 N2 - Abstract.   A survey of the patterns of synonymous codon preference in the HIV env gene reveals a correlation between the codon bias and the mutability requirements of different regions of the protein. At hypervariable regions in gp120 one finds a greater proportion of codons that tend to mutate nonsynonymously, but to a target that is similar in hydrophobicity and volume. We argue that this strategy results from a compromise between the selective pressure placed on the virus by the induced immune response, which favors amino acid substitutions in the complementarity determining regions, and the negative selection against missense mutations that violate structural constraints of the env protein. IS - 4 JF - Journal of Molecular Evolution EP - 397 TI - Codon Bias and Mutability in HIV Sequences VL - 48 SP - 390 KW - bias KW - biology KW - codon KW - evolution KW - genetics KW - sequences AU - Stephens, CR AU - Waelbroeck, H PY - 1999/04/05/ UR - http://dx.doi.org/10.1007/PL00006483 ER -