Timing and mechanism of ancient vertebrate genome duplications - the adventure of a hypothesis Export

@article{citeulike:2362930, abstract = {Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether these were two successive duplications, or whether a single duplication occurred, followed by large-scale segmental duplications. In this article, we review and compare the evidence for the 2R duplications from vertebrate genomes with similar data from other more recent polyploids.}, author = {Panopoulou, Georgia and Poustka, Albert J.}, citeulike-article-id = {2362930}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2005.08.004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16099069}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16099069}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6TCY-4GWBDNN-3/2/0e3dcfe7f3b187e1258d0006c8e305bc}, doi = {10.1016/j.tig.2005.08.004}, journal = {Trends in Genetics}, keywords = {evolution, gene-duplication, genetics, molecular-biology}, month = {October}, number = {10}, pages = {559--567}, posted-at = {2008-10-30 04:08:32}, priority = {2}, title = {Timing and mechanism of ancient vertebrate genome duplications - the adventure of a hypothesis}, url = {http://dx.doi.org/10.1016/j.tig.2005.08.004}, volume = {21}, year = {2005} }

TY - JOUR ID - citeulike:2362930 L3 - citeulike-article-id:2362930 N2 - Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of vertebrates (known as the 2R hypothesis). However, there has been considerable debate as to whether these were two successive duplications, or whether a single duplication occurred, followed by large-scale segmental duplications. In this article, we review and compare the evidence for the 2R duplications from vertebrate genomes with similar data from other more recent polyploids. IS - 10 JF - Trends in Genetics EP - 567 TI - Timing and mechanism of ancient vertebrate genome duplications - the adventure of a hypothesis VL - 21 SP - 559 KW - evolution KW - gene-duplication KW - genetics KW - molecular-biology AU - Panopoulou, Georgia AU - Poustka, Albert PY - 2005/10// UR - http://dx.doi.org/10.1016/j.tig.2005.08.004 ER -