The proliferation of Information Computer and Communication Technologies (IC<SUP align=right>2</SUP>T) throughout the business environment has led to exponentially increasing amounts of data and information. Although these technologies were implemented to enhance and facilitate superior decision-making, the reality is information overload. Knowledge Management (KM) is a recent management technique designed to make sense of this information chaos. Critical to knowledge management is the application of IC<SUP align=right>2</SUP>T. This paper discusses how effective and efficient healthcare operations can ensue through the adoption of a networkcentric healthcare perspective that is grounded in process-oriented knowledge generation and enabled through World Healthcare Information Grid (WHIG).