Osteoclast differentiation and activation Export

@article{citeulike:3479702, abstract = {Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss.}, author = {Boyle, William J. and Simonet, W. Scott and Lacey, David L.}, citeulike-article-id = {3479702}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature01658}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature01658}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12748652}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12748652}, day = {15}, doi = {10.1038/nature01658}, issn = {0028-0836}, journal = {Nature}, keywords = {activation, bmu, bone, osteoblast, osteoclast}, month = {May}, number = {6937}, pages = {337--342}, posted-at = {2008-11-04 17:28:08}, priority = {2}, title = {Osteoclast differentiation and activation}, url = {http://dx.doi.org/10.1038/nature01658}, volume = {423}, year = {2003} }

TY - JOUR ID - citeulike:3479702 L3 - citeulike-article-id:3479702 N2 - Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss. IS - 6937 JF - Nature SN - 0028-0836 EP - 342 TI - Osteoclast differentiation and activation VL - 423 SP - 337 KW - activation KW - bmu KW - bone KW - osteoblast KW - osteoclast AU - Boyle, William AU - Simonet, Scott AU - Lacey, David PY - 2003/05/15/ UR - http://dx.doi.org/10.1038/nature01658 ER -