Human metabolic network reconstruction and its impact on drug discovery and development☆ Export

@article{citeulike:3328250, abstract = {This paper describes the process for the reconstruction of a high quality human metabolic network from the genome information, the existing problems in the reconstruction and why a time-consuming literature based consolidation process is needed. The reconstructed metabolic network provides a unified platform to integrate all the biological and medical information on genes, proteins, metabolites, disease, drugs and drug targets for a system level study of the relationship between metabolism and disease. System analysis of metabolic networks will help us, not only in identifying new drug targets but also in developing a system-oriented drug design strategy.}, address = {School of Informatics, the University of Edinburgh, Mayfield Road, Edinburgh, United Kingdom.}, author = {Ma, H. and Goryanin, I.}, citeulike-article-id = {3328250}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.drudis.2008.02.002}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1359644608000433}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18468557}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18468557}, doi = {10.1016/j.drudis.2008.02.002}, issn = {13596446}, journal = {Drug Discovery Today}, keywords = {metabolic, network}, month = {May}, number = {9-10}, pages = {402--408}, posted-at = {2009-07-20 14:37:40}, priority = {2}, title = {Human metabolic network reconstruction and its impact on drug discovery and development☆}, url = {http://dx.doi.org/10.1016/j.drudis.2008.02.002}, volume = {13}, year = {2008} }

TY - JOUR ID - citeulike:3328250 L3 - citeulike-article-id:3328250 N2 - This paper describes the process for the reconstruction of a high quality human metabolic network from the genome information, the existing problems in the reconstruction and why a time-consuming literature based consolidation process is needed. The reconstructed metabolic network provides a unified platform to integrate all the biological and medical information on genes, proteins, metabolites, disease, drugs and drug targets for a system level study of the relationship between metabolism and disease. System analysis of metabolic networks will help us, not only in identifying new drug targets but also in developing a system-oriented drug design strategy. IS - 9-10 JF - Drug Discovery Today SN - 13596446 AD - School of Informatics, the University of Edinburgh, Mayfield Road, Edinburgh, United Kingdom. EP - 408 TI - Human metabolic network reconstruction and its impact on drug discovery and development☆ VL - 13 SP - 402 KW - metabolic KW - network AU - Ma, H AU - Goryanin, I PY - 2008/05// UR - http://dx.doi.org/10.1016/j.drudis.2008.02.002 ER -