Modern antipsychotic drugs: A critical overview Export

@article{citeulike:2947316, abstract = {Conventional antipsychotic drugs, used for a half century to treat a range of major psychiatric disorders, are being replaced in clinical practice by modern "atypical" antipsychotics, including aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone among others. As a class, the newer drugs have been promoted as being broadly clinically superior, but the evidence for this is problematic. In this brief critical overview, we consider the pharmacology, therapeutic effectiveness, tolerability, adverse effects and costs of individual modern agents versus older antipsychotic drugs. Because of typically minor differences between agents in clinical effectiveness and tolerability, and because of growing concerns about potential adverse long-term health consequences of some modern agents, it is reasonable to consider both older and newer drugs for clinical use, and it is important to inform patients of relative benefits, risks and costs of specific choices. {\copyright} 2005 CMA Media Inc. or its licensors.}, address = {Queen Elizabeth II Health Sciences Centre, 5909 Veterans Memorial Lane, Halifax, NS B3H 2E2, Canada}, author = {Gardner, D. M. and Baldessarini, R. J. and Waraich, P.}, citeulike-article-id = {2947316}, citeulike-linkout-0 = {http://dx.doi.org/10.1503/cmaj.1041064}, citeulike-linkout-1 = {http://www.scopus.com/record/display.url?view=extended&origin=resultslist&eid=2-s2.0-21244487457}, doi = {10.1503/cmaj.1041064}, journal = {Canadian Medical Association Journal}, keywords = {antipsychotic}, number = {13}, pages = {1703--1711}, posted-at = {2008-07-01 10:55:23}, priority = {2}, title = {Modern antipsychotic drugs: A critical overview}, url = {http://dx.doi.org/10.1503/cmaj.1041064}, volume = {172}, year = {2005} }

TY - JOUR ID - citeulike:2947316 L3 - citeulike-article-id:2947316 N2 - Conventional antipsychotic drugs, used for a half century to treat a range of major psychiatric disorders, are being replaced in clinical practice by modern "atypical" antipsychotics, including aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone among others. As a class, the newer drugs have been promoted as being broadly clinically superior, but the evidence for this is problematic. In this brief critical overview, we consider the pharmacology, therapeutic effectiveness, tolerability, adverse effects and costs of individual modern agents versus older antipsychotic drugs. Because of typically minor differences between agents in clinical effectiveness and tolerability, and because of growing concerns about potential adverse long-term health consequences of some modern agents, it is reasonable to consider both older and newer drugs for clinical use, and it is important to inform patients of relative benefits, risks and costs of specific choices. © 2005 CMA Media Inc. or its licensors. IS - 13 JF - Canadian Medical Association Journal AD - Queen Elizabeth II Health Sciences Centre, 5909 Veterans Memorial Lane, Halifax, NS B3H 2E2, Canada EP - 1711 TI - Modern antipsychotic drugs: A critical overview VL - 172 SP - 1703 KW - antipsychotic AU - Gardner, DM AU - Baldessarini, RJ AU - Waraich, P PY - 2005/// UR - http://dx.doi.org/10.1503/cmaj.1041064 ER -