Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity. Export

@article{citeulike:311549, abstract = {There has long been an appreciation that cerebral blood flow is modulated to ensure adequate cerebral oxygen delivery in the face of systemic hypoxaemia. There is increasing appreciation of the modulatory role of hyperoxia in the cerebral circulation and a consideration of the effects of such modulation on the maintenance of cerebral tissue oxygen concentration. These newer findings are particularly important in view of the fact that cerebrovascular and tissue oxygen responses to hyperoxia may change in disease. Such alterations provide important insights into pathophysiological mechanisms and may provide novel targets for therapy. However, before the modulatory effects of hyperoxia can be used for diagnosis, to predict prognosis or to direct therapy, a more detailed analysis and understanding of the physiological concepts behind this modulation are required, as are the limitations of the measurement tools used to define the modulation. This overview summarizes the available information in this area and suggests some avenues for further research.}, address = {University of Cambridge Department of Anaesthetics, Box 93 and Academic Neurosurgery, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. ajj29@cam.ac.uk}, author = {Johnston, A. J. and Steiner, L. A. and Gupta, A. K. and Menon, D. K.}, citeulike-article-id = {311549}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/bja/aeg104}, citeulike-linkout-1 = {http://bja.oxfordjournals.org/cgi/content/abstract/90/6/774}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12765894}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12765894}, doi = {10.1093/bja/aeg104}, issn = {0007-0912}, journal = {Br J Anaesth}, keywords = {healthy, hyperoxia, neurotrauma, review}, month = {June}, number = {6}, pages = {774--786}, posted-at = {2009-01-06 20:59:08}, priority = {0}, title = {Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.}, url = {http://dx.doi.org/10.1093/bja/aeg104}, volume = {90}, year = {2003} }

TY - JOUR ID - citeulike:311549 L3 - citeulike-article-id:311549 N2 - There has long been an appreciation that cerebral blood flow is modulated to ensure adequate cerebral oxygen delivery in the face of systemic hypoxaemia. There is increasing appreciation of the modulatory role of hyperoxia in the cerebral circulation and a consideration of the effects of such modulation on the maintenance of cerebral tissue oxygen concentration. These newer findings are particularly important in view of the fact that cerebrovascular and tissue oxygen responses to hyperoxia may change in disease. Such alterations provide important insights into pathophysiological mechanisms and may provide novel targets for therapy. However, before the modulatory effects of hyperoxia can be used for diagnosis, to predict prognosis or to direct therapy, a more detailed analysis and understanding of the physiological concepts behind this modulation are required, as are the limitations of the measurement tools used to define the modulation. This overview summarizes the available information in this area and suggests some avenues for further research. IS - 6 JF - Br J Anaesth SN - 0007-0912 AD - University of Cambridge Department of Anaesthetics, Box 93 and Academic Neurosurgery, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK. ajj29@cam.ac.uk EP - 786 TI - Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity. VL - 90 SP - 774 KW - healthy KW - hyperoxia KW - neurotrauma KW - review AU - Johnston, AJ AU - Steiner, LA AU - Gupta, AK AU - Menon, DK PY - 2003/06// UR - http://dx.doi.org/10.1093/bja/aeg104 ER -