Measuring Cerebral Oxygenation During Normobaric Hyperoxia: A Comparison of Tissue Microprobes, Near-Infrared Spectroscopy, and Jugular Venous Oximetry in Head Injury Export

@article{citeulike:3855094, abstract = {We measured simultaneous changes in jugular venous oxygen saturation, brain tissue oxygen tension, and cerebral tissue oxygen index by using near-infrared spectroscopy during normobaric hyperoxygenation in eight severely brain-injured patients. Patients were ventilated at their baseline fraction of inspired oxygen (FIO2), followed by stepped changes in FIO2 to 1.0, 0.6, and 0.02-0.05 less than baseline. There was an increase (P < 0.01) in jugular venous saturation (mean {+/-} SD) from a baseline value of 79\% {+/-} 7\% to 89\% {+/-} 6\% and 84\% {+/-} 8\% at an FIO2 of 1.0 and 0.6, respectively. The changes in brain tissue oxygen tension were from a baseline of 30 {+/-} 5 mm Hg to 147 {+/-} 36 mm Hg and 63 {+/-} 6 mm Hg at an FIO2 of 1.0 and 0.6, respectively (P < 0.01). The baseline tissue oxygen index was 78\% {+/-} 3\%, and this increased to 83\% {+/-} 5\% and 80\% {+/-} 4\% at an FIO2 of 1.0 and 0.6, respectively. There was a reduction (P < 0.05) in tissue oxygen index to 76.2\% {+/-} 3.0\% when the FIO2 was reduced to less than baseline. The changes in the three variables followed similar patterns but varied in their degree and speed of response. During brain injury, FIO2 affects measured variables of cerebral oxygenation. IMPLICATIONS: We compared simultaneous measurements of jugular venous saturation, brain tissue oxygen tension, and cerebral tissue oxygen index during normobaric hyperoxia in brain-injured patients. PaO2 influences the output of monitors of cerebral oxygenation, but this does not necessarily equate to improved brain oxygenation.}, author = {Mcleod, Andrew D. and Igielman, Farrell and Elwell, Clare and Cope, Mark and Smith, Martin}, citeulike-article-id = {3855094}, citeulike-linkout-0 = {http://www.anesthesia-analgesia.org/cgi/content/abstract/97/3/851}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12933415}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12933415}, day = {1}, journal = {Anesth Analg}, keywords = {hyperoxia, jugularbulb, licox, neurotrauma, nirs}, month = {September}, number = {3}, pages = {851--856}, posted-at = {2009-01-06 19:58:24}, priority = {3}, title = {Measuring Cerebral Oxygenation During Normobaric Hyperoxia: A Comparison of Tissue Microprobes, Near-Infrared Spectroscopy, and Jugular Venous Oximetry in Head Injury}, url = {http://www.anesthesia-analgesia.org/cgi/content/abstract/97/3/851}, volume = {97}, year = {2003} }

TY - JOUR ID - citeulike:3855094 L3 - citeulike-article-id:3855094 N2 - We measured simultaneous changes in jugular venous oxygen saturation, brain tissue oxygen tension, and cerebral tissue oxygen index by using near-infrared spectroscopy during normobaric hyperoxygenation in eight severely brain-injured patients. Patients were ventilated at their baseline fraction of inspired oxygen (FIO2), followed by stepped changes in FIO2 to 1.0, 0.6, and 0.02-0.05 less than baseline. There was an increase (P < 0.01) in jugular venous saturation (mean {+/-} SD) from a baseline value of 79% {+/-} 7% to 89% {+/-} 6% and 84% {+/-} 8% at an FIO2 of 1.0 and 0.6, respectively. The changes in brain tissue oxygen tension were from a baseline of 30 {+/-} 5 mm Hg to 147 {+/-} 36 mm Hg and 63 {+/-} 6 mm Hg at an FIO2 of 1.0 and 0.6, respectively (P < 0.01). The baseline tissue oxygen index was 78% {+/-} 3%, and this increased to 83% {+/-} 5% and 80% {+/-} 4% at an FIO2 of 1.0 and 0.6, respectively. There was a reduction (P < 0.05) in tissue oxygen index to 76.2% {+/-} 3.0% when the FIO2 was reduced to less than baseline. The changes in the three variables followed similar patterns but varied in their degree and speed of response. During brain injury, FIO2 affects measured variables of cerebral oxygenation. IMPLICATIONS: We compared simultaneous measurements of jugular venous saturation, brain tissue oxygen tension, and cerebral tissue oxygen index during normobaric hyperoxia in brain-injured patients. PaO2 influences the output of monitors of cerebral oxygenation, but this does not necessarily equate to improved brain oxygenation. IS - 3 JF - Anesth Analg EP - 856 TI - Measuring Cerebral Oxygenation During Normobaric Hyperoxia: A Comparison of Tissue Microprobes, Near-Infrared Spectroscopy, and Jugular Venous Oximetry in Head Injury VL - 97 SP - 851 KW - hyperoxia KW - jugularbulb KW - licox KW - neurotrauma KW - nirs AU - Mcleod, Andrew AU - Igielman, Farrell AU - Elwell, Clare AU - Cope, Mark AU - Smith, Martin PY - 2003/09/01/ UR - http://www.anesthesia-analgesia.org/cgi/content/abstract/97/3/851 ER -