PDZ domain proteins of synapses Export

@article{citeulike:2318228, abstract = {PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large molecular complexes at defined locations in the cell. In the postsynaptic density of neuronal excitatory synapses, PDZ proteins such as PSD-95 organize glutamate receptors and their associated signalling proteins and determine the size and strength of synapses. PDZ scaffolds also function in the dynamic trafficking of synaptic proteins by assembling cargo complexes for transport by molecular motors. As key organizers that control synaptic protein composition and structure, PDZ scaffolds are themselves highly regulated by synthesis and degradation, subcellular distribution and post-translational modification.}, address = {National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong-dong, Yuseong-gu, Daejeon 305-701, Korea. kime@kaist.ac.kr}, author = {Kim, Eunjoon and Sheng, Morgan}, citeulike-article-id = {2318228}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrn1517}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrn1517}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15378037}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15378037}, doi = {10.1038/nrn1517}, issn = {1471-003X}, journal = {Nat Rev Neurosci}, keywords = {autoinhibition, pdz, review, zev-class}, month = {October}, number = {10}, pages = {771--781}, posted-at = {2008-03-11 23:33:27}, priority = {0}, title = {PDZ domain proteins of synapses}, url = {http://dx.doi.org/10.1038/nrn1517}, volume = {5}, year = {2004} }

TY - JOUR ID - citeulike:2318228 L3 - citeulike-article-id:2318228 N2 - PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large molecular complexes at defined locations in the cell. In the postsynaptic density of neuronal excitatory synapses, PDZ proteins such as PSD-95 organize glutamate receptors and their associated signalling proteins and determine the size and strength of synapses. PDZ scaffolds also function in the dynamic trafficking of synaptic proteins by assembling cargo complexes for transport by molecular motors. As key organizers that control synaptic protein composition and structure, PDZ scaffolds are themselves highly regulated by synthesis and degradation, subcellular distribution and post-translational modification. IS - 10 JF - Nat Rev Neurosci SN - 1471-003X AD - National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Guseong-dong, Yuseong-gu, Daejeon 305-701, Korea. kime@kaist.ac.kr EP - 781 TI - PDZ domain proteins of synapses VL - 5 SP - 771 KW - autoinhibition KW - pdz KW - review KW - zev-class AU - Kim, Eunjoon AU - Sheng, Morgan PY - 2004/10// UR - http://dx.doi.org/10.1038/nrn1517 ER -