Bacteria Subsisting on Antibiotics Export

@article{citeulike:2628746, abstract = {Antibiotics are a crucial line of defense against bacterial infections. Nevertheless, several antibiotics are natural products of microorganisms that have as yet poorly appreciated ecological roles in the wider environment. We isolated hundreds of soil bacteria with the capacity to grow on antibiotics as a sole carbon source. Of 18 antibiotics tested, representing eight major classes of natural and synthetic origin, 13 to 17 supported the growth of clonal bacteria from each of 11 diverse soils. Bacteria subsisting on antibiotics are surprisingly phylogenetically diverse, and many are closely related to human pathogens. Furthermore, each antibiotic-consuming isolate was resistant to multiple antibiotics at clinically relevant concentrations. This phenomenon suggests that this unappreciated reservoir of antibiotic-resistance determinants can contribute to the increasing levels of multiple antibiotic resistance in pathogenic bacteria. 10.1126/science.1155157}, author = {Dantas, Gautam and Sommer, Morten O. and Oluwasegun, Rantimi D. and Church, George M.}, citeulike-article-id = {2628746}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1155157}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/320/5872/100}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18388292}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18388292}, day = {4}, doi = {10.1126/science.1155157}, journal = {Science}, keywords = {antibiotics, bacteria, fun, off-topic}, month = {April}, number = {5872}, pages = {100--103}, posted-at = {2008-04-04 19:20:15}, priority = {2}, title = {Bacteria Subsisting on Antibiotics}, url = {http://dx.doi.org/10.1126/science.1155157}, volume = {320}, year = {2008} }

TY - JOUR ID - citeulike:2628746 L3 - citeulike-article-id:2628746 N2 - Antibiotics are a crucial line of defense against bacterial infections. Nevertheless, several antibiotics are natural products of microorganisms that have as yet poorly appreciated ecological roles in the wider environment. We isolated hundreds of soil bacteria with the capacity to grow on antibiotics as a sole carbon source. Of 18 antibiotics tested, representing eight major classes of natural and synthetic origin, 13 to 17 supported the growth of clonal bacteria from each of 11 diverse soils. Bacteria subsisting on antibiotics are surprisingly phylogenetically diverse, and many are closely related to human pathogens. Furthermore, each antibiotic-consuming isolate was resistant to multiple antibiotics at clinically relevant concentrations. This phenomenon suggests that this unappreciated reservoir of antibiotic-resistance determinants can contribute to the increasing levels of multiple antibiotic resistance in pathogenic bacteria. 10.1126/science.1155157 IS - 5872 JF - Science EP - 103 TI - Bacteria Subsisting on Antibiotics VL - 320 SP - 100 KW - antibiotics KW - bacteria KW - fun KW - off-topic AU - Dantas, Gautam AU - Sommer, Morten AU - Oluwasegun, Rantimi AU - Church, George PY - 2008/04/04/ UR - http://dx.doi.org/10.1126/science.1155157 ER -