Fluorescent Probes for Chemical Transformations on the Single-Molecule Level Export

@article{citeulike:3043825, abstract = {We highlight our recent achievements in the design of fluorescent dyes for the investigation of chemical reactions on the single-molecule level. These fluorophores are tailored to undergo changes in their photophysical properties upon chemical transformations. Three examples are presented: electrophilic aromatic substitution, phosphoester cleavage, and oxidation of double-bonds. Thin-layer chromatography and fluorescence correlation spectroscopy are used to separate and characterize the different reaction products, respectively. We are planning to develop more fluorescent synthons which enable us to perform single-molecule chemistry of various reactions. 10.1196/annals.1430.006}, author = {Jung, Gregor and Schmitt, Alexander and Jacob, Michaela and Hinkeldey, Babette}, citeulike-article-id = {3043825}, citeulike-linkout-0 = {http://dx.doi.org/10.1196/annals.1430.006}, citeulike-linkout-1 = {http://www.annalsnyas.org/cgi/content/abstract/1130/1/131}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18596341}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18596341}, citeulike-linkout-4 = {http://www3.interscience.wiley.com/cgi-bin/abstract/119880540/ABSTRACT}, day = {1}, doi = {10.1196/annals.1430.006}, journal = {Ann NY Acad Sci}, keywords = {chemistry-sensitive-fluorophore, fluorophore, single-molecule}, month = {May}, number = {1}, pages = {131--137}, posted-at = {2008-07-29 20:27:32}, priority = {2}, title = {Fluorescent Probes for Chemical Transformations on the Single-Molecule Level}, url = {http://dx.doi.org/10.1196/annals.1430.006}, volume = {1130}, year = {2008} }

TY - JOUR ID - citeulike:3043825 L3 - citeulike-article-id:3043825 N2 - We highlight our recent achievements in the design of fluorescent dyes for the investigation of chemical reactions on the single-molecule level. These fluorophores are tailored to undergo changes in their photophysical properties upon chemical transformations. Three examples are presented: electrophilic aromatic substitution, phosphoester cleavage, and oxidation of double-bonds. Thin-layer chromatography and fluorescence correlation spectroscopy are used to separate and characterize the different reaction products, respectively. We are planning to develop more fluorescent synthons which enable us to perform single-molecule chemistry of various reactions. 10.1196/annals.1430.006 IS - 1 JF - Ann NY Acad Sci EP - 137 TI - Fluorescent Probes for Chemical Transformations on the Single-Molecule Level VL - 1130 SP - 131 KW - chemistry-sensitive-fluorophore KW - fluorophore KW - single-molecule AU - Jung, Gregor AU - Schmitt, Alexander AU - Jacob, Michaela AU - Hinkeldey, Babette PY - 2008/05/01/ UR - http://dx.doi.org/10.1196/annals.1430.006 ER -