Yeast and drug discovery. Export

@article{hughes2002, abstract = {Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast have been in widespread use less than a decade - a period shorter than the typical cycle from target identification to marketing approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds have yet to be realized.}, address = {Banting and Best Department of Medical Research, University of Toronto, 112 College St., Toronto, ON M5G 1L6, Canada. t.hughes@utoronto.ca}, author = {Hughes, T. R.}, citeulike-article-id = {1447870}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s10142-002-0059-1}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12192593}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12192593}, doi = {10.1007/s10142-002-0059-1}, issn = {1438-793X}, journal = {Functional \& Integrative Genomics}, keywords = {mdb-thesis, yeast}, month = {September}, number = {4-5}, pages = {199--211}, posted-at = {2009-07-03 12:14:10}, priority = {2}, title = {Yeast and drug discovery.}, url = {http://dx.doi.org/10.1007/s10142-002-0059-1}, volume = {2}, year = {2002} }

TY - JOUR ID - hughes2002 L3 - citeulike-article-id:1447870 N2 - Advanced genetic techniques, along with the high degree of conservation of basic cellular processes, have made the yeast Saccharomyces cerevisiae a valuable system for identification of new drug targets, target-based and non-target-based drug screening, and detailed analysis of the cellular effects of drugs. Yeast also presents a convenient system for antifungal drug discovery because it is closely related to Candida albicans, a major human pathogen. Many yeast genes remain poorly characterized, and most of the sophisticated techniques in yeast have been in widespread use less than a decade - a period shorter than the typical cycle from target identification to marketing approval for a new drug. It is likely that most of the benefits of yeast in discovery and development of therapeutic compounds have yet to be realized. IS - 4-5 JF - Functional & Integrative Genomics SN - 1438-793X AD - Banting and Best Department of Medical Research, University of Toronto, 112 College St., Toronto, ON M5G 1L6, Canada. t.hughes@utoronto.ca EP - 211 TI - Yeast and drug discovery. VL - 2 SP - 199 KW - mdb-thesis KW - yeast AU - Hughes, TR PY - 2002/09// UR - http://dx.doi.org/10.1007/s10142-002-0059-1 ER -