Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. Export

@article{pritchard2002, abstract = {We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.}, address = {Institute of Biological Sciences, University of Wales, Aberystwyth, UK.}, author = {Pritchard, L. and Kell, D. B.}, citeulike-article-id = {306}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12180966}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12180966}, issn = {0014-2956}, journal = {Eur J Biochem}, keywords = {energy-production, glycolysis, kinetic-modelling, metabolic-control-analysis, metabolism, metabolomics, model-fitting, paramter-scanning, reviewed, systems-biology, yeast}, month = {August}, number = {16}, pages = {3894--3904}, posted-at = {2009-01-15 16:51:13}, priority = {0}, title = {Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12180966}, volume = {269}, year = {2002} }

TY - JOUR ID - pritchard2002 L3 - citeulike-article-id:306 N2 - We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control. IS - 16 JF - Eur J Biochem SN - 0014-2956 AD - Institute of Biological Sciences, University of Wales, Aberystwyth, UK. EP - 3904 TI - Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. VL - 269 SP - 3894 KW - energy-production KW - glycolysis KW - kinetic-modelling KW - metabolic-control-analysis KW - metabolism KW - metabolomics KW - model-fitting KW - paramter-scanning KW - reviewed KW - systems-biology KW - yeast AU - Pritchard, L AU - Kell, DB PY - 2002/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/12180966 ER -