Why highly expressed proteins evolve slowly Export

@article{drummond2005, abstract = {10.1073/pnas.0504070102 Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that have remained unexplained. Here, we hypothesize that selection to reduce the burden of protein misfolding will favor protein sequences with increased robustness to translational missense errors. Pressure for translational robustness increases with expression level and constrains sequence evolution. Using several sequenced yeast genomes, global expression and protein abundance data, and sets of paralogs traceable to an ancient whole-genome duplication in yeast, we rule out several confounding effects and show that expression level explains roughly half the variation in protein evolutionary rates. We examine causes for expression's dominant role and find that genome-wide tests favor the translational robustness explanation over existing hypotheses that invoke constraints on function or translational efficiency. Our results suggest that proteins evolve at rates largely unrelated to their functions and can explain why highly expressed proteins evolve slowly across the tree of life.}, address = {Program in Computation and Neural Systems and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125-4100.}, author = {Drummond, D. A. A. and Bloom, Jesse D. D. and Adami, Christoph and Wilke, Claus O. O. and Arnold, Frances H. H.}, booktitle = {Proceedings of the National Academy of Sciences of the United States of America}, citeulike-article-id = {341106}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0504070102}, citeulike-linkout-1 = {http://www.pnas.org/content/102/40/14338.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/102/40/14338.full.pdf}, citeulike-linkout-3 = {http://www.pnas.org/cgi/content/abstract/102/40/14338}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/16176987}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=16176987}, day = {4}, doi = {10.1073/pnas.0504070102}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences}, keywords = {evolutionary-rate, gene-expression, mdb-thesis, prote-evolution}, month = {October}, number = {40}, pages = {14338--14343}, posted-at = {2009-06-15 11:45:50}, priority = {0}, title = {Why highly expressed proteins evolve slowly}, url = {http://dx.doi.org/10.1073/pnas.0504070102}, volume = {102}, year = {2005} }

TY - JOUR ID - drummond2005 L3 - citeulike-article-id:341106 N2 - 10.1073/pnas.0504070102 Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that have remained unexplained. Here, we hypothesize that selection to reduce the burden of protein misfolding will favor protein sequences with increased robustness to translational missense errors. Pressure for translational robustness increases with expression level and constrains sequence evolution. Using several sequenced yeast genomes, global expression and protein abundance data, and sets of paralogs traceable to an ancient whole-genome duplication in yeast, we rule out several confounding effects and show that expression level explains roughly half the variation in protein evolutionary rates. We examine causes for expression's dominant role and find that genome-wide tests favor the translational robustness explanation over existing hypotheses that invoke constraints on function or translational efficiency. Our results suggest that proteins evolve at rates largely unrelated to their functions and can explain why highly expressed proteins evolve slowly across the tree of life. IS - 40 JF - Proceedings of the National Academy of Sciences SN - 0027-8424 AD - Program in Computation and Neural Systems and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125-4100. EP - 14343 TI - Why highly expressed proteins evolve slowly VL - 102 T2 - Proceedings of the National Academy of Sciences of the United States of America SP - 14338 KW - evolutionary-rate KW - gene-expression KW - mdb-thesis KW - prote-evolution AU - Drummond, DAA AU - Bloom, Jesse AU - Adami, Christoph AU - Wilke, Claus AU - Arnold, Frances PY - 2005/10/04/ UR - http://dx.doi.org/10.1073/pnas.0504070102 ER -