Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes. Export

@article{bragg2007, abstract = {Natural selection can influence even the lowest level of biological organization, the atomic composition of biological macromolecules. In analysing genome-scale gene expression data, we find that ancestral yeast strains preferentially express proteins with low carbon content during carbon limitation, relative to strains selected in the laboratory under carbon limitation. The likely reason is that the artificially selected strains acquire adaptations that refine their response to the limitation or partly circumvent the limiting condition. This finding extends previous work which shows that natural selection can act on the atomic costs of proteins. We also show that genes with high carbon and nitrogen content are less likely to have duplicates, indicating that atomic composition also plays a role in evolution by gene duplication. Taken together, our results contribute to the emerging view that protein atomic composition influences genome and transcriptome evolution.}, author = {Bragg, J. G. and Wagner, A.}, citeulike-article-id = {4120548}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rspb.2006.0290}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17264057}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17264057}, day = {22}, doi = {10.1098/rspb.2006.0290}, issn = {0962-8452}, journal = {Proceedings of the Royal Society B}, keywords = {atomic-content, gene-duplication, mdb-thesis}, month = {April}, number = {1613}, pages = {1063--1070}, posted-at = {2009-03-02 22:38:26}, priority = {0}, title = {Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes.}, url = {http://dx.doi.org/10.1098/rspb.2006.0290}, volume = {274}, year = {2007} }

TY - JOUR ID - bragg2007 L3 - citeulike-article-id:4120548 N2 - Natural selection can influence even the lowest level of biological organization, the atomic composition of biological macromolecules. In analysing genome-scale gene expression data, we find that ancestral yeast strains preferentially express proteins with low carbon content during carbon limitation, relative to strains selected in the laboratory under carbon limitation. The likely reason is that the artificially selected strains acquire adaptations that refine their response to the limitation or partly circumvent the limiting condition. This finding extends previous work which shows that natural selection can act on the atomic costs of proteins. We also show that genes with high carbon and nitrogen content are less likely to have duplicates, indicating that atomic composition also plays a role in evolution by gene duplication. Taken together, our results contribute to the emerging view that protein atomic composition influences genome and transcriptome evolution. IS - 1613 JF - Proceedings of the Royal Society B SN - 0962-8452 EP - 1070 TI - Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes. VL - 274 SP - 1063 KW - atomic-content KW - gene-duplication KW - mdb-thesis AU - Bragg, JG AU - Wagner, A PY - 2007/04/22/ UR - http://dx.doi.org/10.1098/rspb.2006.0290 ER -