Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences Export

@article{citeulike:5942169, abstract = {Viruses differ markedly in their specificity toward host organisms. Here, we test the level of general sequence adaptation that viruses display toward their hosts. We compiled a representative data set of viruses that infect hosts ranging from bacteria to humans. We consider their respective amino acid and codon usages and compare them among the viruses and their hosts. We show that bacteria-infecting viruses are strongly adapted to their specific hosts, but that they differ from other unrelated bacterial hosts. Viruses that infect humans, but not those that infect other mammals or aves, show a strong resemblance to most mammalian and avian hosts, in terms of both amino acid and codon preferences. In groups of viruses that infect humans or other mammals, the highest observed level of adaptation of viral proteins to host codon usages is for those proteins that appear abundantly in the virion. In contrast, proteins that are known to participate in host-specific recognition do not necessarily adapt to their respective hosts. The implication for the potential of viral infectivity is discussed.}, author = {Bahir, Iris and Fromer, Menachem and Prat, Yosef and Linial, Michal}, citeulike-article-id = {5942169}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/msb.2009.71}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/msb200971}, day = {13}, doi = {10.1038/msb.2009.71}, journal = {Molecular Systems Biology}, keywords = {amino-acid-usage, virus}, month = {October}, posted-at = {2009-11-06 17:01:12}, priority = {5}, publisher = {Nature Publishing Group}, title = {Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences}, url = {http://dx.doi.org/10.1038/msb.2009.71}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5942169 L3 - citeulike-article-id:5942169 N2 - Viruses differ markedly in their specificity toward host organisms. Here, we test the level of general sequence adaptation that viruses display toward their hosts. We compiled a representative data set of viruses that infect hosts ranging from bacteria to humans. We consider their respective amino acid and codon usages and compare them among the viruses and their hosts. We show that bacteria-infecting viruses are strongly adapted to their specific hosts, but that they differ from other unrelated bacterial hosts. Viruses that infect humans, but not those that infect other mammals or aves, show a strong resemblance to most mammalian and avian hosts, in terms of both amino acid and codon preferences. In groups of viruses that infect humans or other mammals, the highest observed level of adaptation of viral proteins to host codon usages is for those proteins that appear abundantly in the virion. In contrast, proteins that are known to participate in host-specific recognition do not necessarily adapt to their respective hosts. The implication for the potential of viral infectivity is discussed. JF - Molecular Systems Biology TI - Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences PB - Nature Publishing Group VL - 5 KW - amino-acid-usage KW - virus AU - Bahir, Iris AU - Fromer, Menachem AU - Prat, Yosef AU - Linial, Michal PY - 2009/10/13/ UR - http://dx.doi.org/10.1038/msb.2009.71 ER -