Applications of genome-scale metabolic reconstructions Export

@article{citeulike:6069163, abstract = {The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.}, author = {Oberhardt, Matthew A. and Palsson, Bernhard O. and Papin, Jason A.}, citeulike-article-id = {6069163}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/msb.2009.77}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/msb200977}, day = {03}, doi = {10.1038/msb.2009.77}, journal = {Molecular Systems Biology}, keywords = {genome-scale-model}, month = {November}, posted-at = {2009-11-06 16:55:47}, priority = {4}, publisher = {Nature Publishing Group}, title = {Applications of genome-scale metabolic reconstructions}, url = {http://dx.doi.org/10.1038/msb.2009.77}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:6069163 L3 - citeulike-article-id:6069163 N2 - The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology. JF - Molecular Systems Biology TI - Applications of genome-scale metabolic reconstructions PB - Nature Publishing Group VL - 5 KW - genome-scale-model AU - Oberhardt, Matthew AU - Palsson, Bernhard AU - Papin, Jason PY - 2009/11/03/ UR - http://dx.doi.org/10.1038/msb.2009.77 ER -