Outpatient management of uncomplicated lower-extremity infections in diabetic patients. Export

@article{citeulike:4090964, abstract = {Most diabetic foot infections are believed to be caused by both aerobic and anaerobic bacteria and to require hospitalization and parenteral antimicrobial therapy. We prospectively evaluated diabetic patients with non-limb-threatening lower-extremity infections not yet treated with antibiotics. The patients were randomized to outpatient treatment with oral clindamycin hydrochloride or cephalexin for 2 weeks and evaluated every 3 to 7 days. In 56 assessable patients, curettage yielded a mean of 2.1 microorganisms. Aerobic gram-positive cocci were isolated in 50 cases (89\%), and were the sole pathogen in 21 (42\%) of these. Aerobic gram-negative bacilli and anaerobes were isolated in 20 (36\%) and 7 (13\%) cases, respectively, and almost always in polymicrobial infections. Fifty-one infections (91\%) were eradicated, 42 (75\%) after 2 weeks of treatment; only 5 (9\%) were initially treatment failures, and 3 (5\%) were subsequently cured with further outpatient oral antibiotic treatment. After a mean follow-up of 15 months, no further treatment was required in 43 (84\%) of the cured patients. Previously untreated lower-extremity infections in diabetic patients are usually caused by aerobic gram-positive cocci, and generally respond well to outpatient management with oral antibiotic therapy.}, author = {Lipsky, B. A. and Pecoraro, R. E. and Larson, S. A. and Hanley, M. E. and Ahroni, J. H.}, citeulike-article-id = {4090964}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2183732}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2183732}, comment = {pdf not available }, issn = {0003-9926}, journal = {Archives of internal medicine}, keywords = {dfi}, month = {April}, number = {4}, pages = {790--797}, posted-at = {2009-02-24 03:41:23}, priority = {2}, title = {Outpatient management of uncomplicated lower-extremity infections in diabetic patients.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2183732}, volume = {150}, year = {1990} }

TY - JOUR ID - citeulike:4090964 L3 - citeulike-article-id:4090964 N2 - Most diabetic foot infections are believed to be caused by both aerobic and anaerobic bacteria and to require hospitalization and parenteral antimicrobial therapy. We prospectively evaluated diabetic patients with non-limb-threatening lower-extremity infections not yet treated with antibiotics. The patients were randomized to outpatient treatment with oral clindamycin hydrochloride or cephalexin for 2 weeks and evaluated every 3 to 7 days. In 56 assessable patients, curettage yielded a mean of 2.1 microorganisms. Aerobic gram-positive cocci were isolated in 50 cases (89%), and were the sole pathogen in 21 (42%) of these. Aerobic gram-negative bacilli and anaerobes were isolated in 20 (36%) and 7 (13%) cases, respectively, and almost always in polymicrobial infections. Fifty-one infections (91%) were eradicated, 42 (75%) after 2 weeks of treatment; only 5 (9%) were initially treatment failures, and 3 (5%) were subsequently cured with further outpatient oral antibiotic treatment. After a mean follow-up of 15 months, no further treatment was required in 43 (84%) of the cured patients. Previously untreated lower-extremity infections in diabetic patients are usually caused by aerobic gram-positive cocci, and generally respond well to outpatient management with oral antibiotic therapy. IS - 4 JF - Archives of internal medicine SN - 0003-9926 EP - 797 TI - Outpatient management of uncomplicated lower-extremity infections in diabetic patients. VL - 150 SP - 790 KW - dfi N1 - pdf not available AU - Lipsky, BA AU - Pecoraro, RE AU - Larson, SA AU - Hanley, ME AU - Ahroni, JH PY - 1990/04// UR - http://view.ncbi.nlm.nih.gov/pubmed/2183732 ER -