The effect of diabetes and severe ischaemia on the penetration of ceftazidime into tissues of the limb. Export

@article{citeulike:4090973, abstract = {AIMS: To determine the effect of diabetes and of different degrees of ischaemia on the penetration of ceftazidime into different tissues. METHODS: Sixteen patients (10 with diabetes mellitus) undergoing lower extremity amputation for severe ischaemia (in 12 in combination with infection), received 2000 mg ceftazidime intravenously as a bolus 30 min prior to the operation. Skin perfusion was determined by transcutaneous oxygen pressure measurements (TcPO2) on the dorsal side of the midfoot. After amputation bone, skin and muscle samples were obtained from the forefoot, midfoot and proximal tibia. Tissue and plasma concentrations were determined by HPLC. The tissue concentrations were corrected for blood contamination. RESULTS: No differences were observed in skin, muscle or bone ceftazidime levels between diabetic and non-diabetic patients. Multiple regression analysis suggested that tissue perfusion was a major determinant of skin and bone ceftazidime concentrations, predicting 40-47\% of the ceftazidime concentrations at several biopsy sites. CONCLUSIONS: The present study suggests that tissue perfusion is the major determinant of the penetration of a third generation cephalosporin into the tissues of the ischaemic (diabetic) foot. Diabetes alone however, has no major effects upon this penetration.}, author = {Raymakers, J. T. and Houben, A. J. and van der Heyden, J. J. and Tordoir, J. H. and Kitslaar, P. J. and Schaper, N. C.}, citeulike-article-id = {4090973}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11318845}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11318845}, comment = {pdf not available }, issn = {0742-3071}, journal = {Diabetic medicine : a journal of the British Diabetic Association}, keywords = {dfi}, month = {March}, number = {3}, pages = {229--234}, posted-at = {2009-02-24 03:53:48}, priority = {2}, title = {The effect of diabetes and severe ischaemia on the penetration of ceftazidime into tissues of the limb.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11318845}, volume = {18}, year = {2001} }

TY - JOUR ID - citeulike:4090973 L3 - citeulike-article-id:4090973 N2 - AIMS: To determine the effect of diabetes and of different degrees of ischaemia on the penetration of ceftazidime into different tissues. METHODS: Sixteen patients (10 with diabetes mellitus) undergoing lower extremity amputation for severe ischaemia (in 12 in combination with infection), received 2000 mg ceftazidime intravenously as a bolus 30 min prior to the operation. Skin perfusion was determined by transcutaneous oxygen pressure measurements (TcPO2) on the dorsal side of the midfoot. After amputation bone, skin and muscle samples were obtained from the forefoot, midfoot and proximal tibia. Tissue and plasma concentrations were determined by HPLC. The tissue concentrations were corrected for blood contamination. RESULTS: No differences were observed in skin, muscle or bone ceftazidime levels between diabetic and non-diabetic patients. Multiple regression analysis suggested that tissue perfusion was a major determinant of skin and bone ceftazidime concentrations, predicting 40-47% of the ceftazidime concentrations at several biopsy sites. CONCLUSIONS: The present study suggests that tissue perfusion is the major determinant of the penetration of a third generation cephalosporin into the tissues of the ischaemic (diabetic) foot. Diabetes alone however, has no major effects upon this penetration. IS - 3 JF - Diabetic medicine : a journal of the British Diabetic Association SN - 0742-3071 EP - 234 TI - The effect of diabetes and severe ischaemia on the penetration of ceftazidime into tissues of the limb. VL - 18 SP - 229 KW - dfi N1 - pdf not available AU - Raymakers, JT AU - Houben, AJ AU - van der Heyden, JJ AU - Tordoir, JH AU - Kitslaar, PJ AU - Schaper, NC PY - 2001/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/11318845 ER -