Tissue concentrations after a single-dose, orally administered ofloxacin in patients with diabetic foot infections. Export

@article{citeulike:4090987, abstract = {We studied the penetration of orally administered ofloxacin at the site of diabetes-related foot infections in patients with a planned debridement of the lesion. A total of nine patients received 800 mg of oral ofloxacin 120 to 150 minutes before surgery. During surgery, vital margin tissue and a serum sample were obtained. Serum and tissue concentrations of ofloxacin were measured. From seven patients sufficient amounts of tissue were obtained. Mean serum concentration was 7.0+/-3.5 mg/liter; mean tissue concentrations was 11.5+/-8.4 mg/kg. Mean serum and tissue concentrations exceed the minimal inhibitory concentration90 (MIC90) of commonly involved pathogens. This indicates that orally administered ofloxacin can be an effective treatment for infected diabetic foot lesions.}, author = {Kuck, E. M. and Bouter, K. P. and Hoekstra, J. B. and Conemans, J. M. and Diepersloot, R. J.}, citeulike-article-id = {4090987}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9462911}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9462911}, comment = {pdf not available}, issn = {1071-1007}, journal = {Foot \& ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society}, keywords = {dfi}, month = {January}, number = {1}, pages = {38--40}, posted-at = {2009-02-24 04:13:48}, priority = {2}, title = {Tissue concentrations after a single-dose, orally administered ofloxacin in patients with diabetic foot infections.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9462911}, volume = {19}, year = {1998} }

TY - JOUR ID - citeulike:4090987 L3 - citeulike-article-id:4090987 N2 - We studied the penetration of orally administered ofloxacin at the site of diabetes-related foot infections in patients with a planned debridement of the lesion. A total of nine patients received 800 mg of oral ofloxacin 120 to 150 minutes before surgery. During surgery, vital margin tissue and a serum sample were obtained. Serum and tissue concentrations of ofloxacin were measured. From seven patients sufficient amounts of tissue were obtained. Mean serum concentration was 7.0+/-3.5 mg/liter; mean tissue concentrations was 11.5+/-8.4 mg/kg. Mean serum and tissue concentrations exceed the minimal inhibitory concentration90 (MIC90) of commonly involved pathogens. This indicates that orally administered ofloxacin can be an effective treatment for infected diabetic foot lesions. IS - 1 JF - Foot & ankle international / American Orthopaedic Foot and Ankle Society [and] Swiss Foot and Ankle Society SN - 1071-1007 EP - 40 TI - Tissue concentrations after a single-dose, orally administered ofloxacin in patients with diabetic foot infections. VL - 19 SP - 38 KW - dfi N1 - pdf not available AU - Kuck, EM AU - Bouter, KP AU - Hoekstra, JB AU - Conemans, JM AU - Diepersloot, RJ PY - 1998/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/9462911 ER -