Is protein folding hierarchic? II. Folding intermediates and transition states. Export

@article{citeulike:3433705, abstract = {The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the literature have been interpreted to the contrary. For these examples, we have simulated the local structures that form when folding begins by using the LINUS program with nonlocal interactions turned off. Our results support a hierarchic model of protein folding.}, author = {Baldwin, R. L. and Rose, G. D.}, citeulike-article-id = {3433705}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10098403}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10098403}, issn = {0968-0004}, journal = {Trends in biochemical sciences}, keywords = {folding}, month = {February}, number = {2}, pages = {77--83}, posted-at = {2008-10-21 13:54:22}, priority = {2}, title = {Is protein folding hierarchic? II. Folding intermediates and transition states.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10098403}, volume = {24}, year = {1999} }

TY - JOUR ID - citeulike:3433705 L3 - citeulike-article-id:3433705 N2 - The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the literature have been interpreted to the contrary. For these examples, we have simulated the local structures that form when folding begins by using the LINUS program with nonlocal interactions turned off. Our results support a hierarchic model of protein folding. IS - 2 JF - Trends in biochemical sciences SN - 0968-0004 EP - 83 TI - Is protein folding hierarchic? II. Folding intermediates and transition states. VL - 24 SP - 77 KW - folding AU - Baldwin, RL AU - Rose, GD PY - 1999/02// UR - http://view.ncbi.nlm.nih.gov/pubmed/10098403 ER -