Basal-like breast cancer: a critical review. Export

@article{citeulike:3255421, abstract = {Recent gene expression profiling of breast cancer has identified specific subtypes with clinical, biologic, and therapeutic implications. The basal-like group of tumors is characterized by an expression signature similar to that of the basal/myoepithelial cells of the breast and is reported to have transcriptomic characteristics similar to those of tumors arising in BRCA1 germline mutation carriers. They are associated with aggressive behavior and poor prognosis, and typically do not express hormone receptors or HER-2 ("triple-negative" phenotype). Therefore, patients with basal-like cancers are unlikely to benefit from currently available targeted systemic therapy. Although basal-like tumors are characterized by distinctive morphologic, genetic, immunophenotypic, and clinical features, neither an accepted consensus on routine clinical identification and definition of this aggressive subtype of breast cancer nor a way of systematically classifying this complex group of tumors has been described. Different definitions are, therefore, likely to produce variable and contradictory results that may hamper consistent identification and development of treatment strategies for these tumors. In this review, we discuss definition, heterogeneity, morphologic spectrum, relation to BRCA1, and clinical significance of this important class of breast cancer.}, author = {Rakha, Emad A. and Reis-Filho, Jorge S. and Ellis, Ian O.}, citeulike-article-id = {3255421}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2007.13.1748}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/26/15/2568.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/26/15/2568.full.pdf}, citeulike-linkout-3 = {http://jco.ascopubs.org/cgi/content/abstract/26/15/2568}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/18487574}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=18487574}, day = {20}, doi = {10.1200/JCO.2007.13.1748}, issn = {1527-7755}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, keywords = {basal-like, breast, review, triple-negative}, month = {May}, number = {15}, pages = {2568--2581}, posted-at = {2009-11-10 05:57:30}, priority = {2}, title = {Basal-like breast cancer: a critical review.}, url = {http://dx.doi.org/10.1200/JCO.2007.13.1748}, volume = {26}, year = {2008} }

TY - JOUR ID - citeulike:3255421 L3 - citeulike-article-id:3255421 N2 - Recent gene expression profiling of breast cancer has identified specific subtypes with clinical, biologic, and therapeutic implications. The basal-like group of tumors is characterized by an expression signature similar to that of the basal/myoepithelial cells of the breast and is reported to have transcriptomic characteristics similar to those of tumors arising in BRCA1 germline mutation carriers. They are associated with aggressive behavior and poor prognosis, and typically do not express hormone receptors or HER-2 ("triple-negative" phenotype). Therefore, patients with basal-like cancers are unlikely to benefit from currently available targeted systemic therapy. Although basal-like tumors are characterized by distinctive morphologic, genetic, immunophenotypic, and clinical features, neither an accepted consensus on routine clinical identification and definition of this aggressive subtype of breast cancer nor a way of systematically classifying this complex group of tumors has been described. Different definitions are, therefore, likely to produce variable and contradictory results that may hamper consistent identification and development of treatment strategies for these tumors. In this review, we discuss definition, heterogeneity, morphologic spectrum, relation to BRCA1, and clinical significance of this important class of breast cancer. IS - 15 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology SN - 1527-7755 EP - 2581 TI - Basal-like breast cancer: a critical review. VL - 26 SP - 2568 KW - basal-like KW - breast KW - review KW - triple-negative AU - Rakha, Emad AU - Reis-Filho, Jorge AU - Ellis, Ian PY - 2008/05/20/ UR - http://dx.doi.org/10.1200/JCO.2007.13.1748 ER -