ATM and related protein kinases: safeguarding genome integrity. Export

@article{citeulike:3333128, abstract = {Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response--a cornerstone of genome stability--occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.}, address = {The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il}, author = {Shiloh, Y.}, citeulike-article-id = {3333128}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrc1011}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12612651}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12612651}, doi = {10.1038/nrc1011}, issn = {1474-175X}, journal = {Nature Reviews Cancer}, keywords = {atm, dna\_repair, review}, month = {March}, number = {3}, pages = {155--168}, posted-at = {2008-09-24 18:25:59}, priority = {2}, title = {ATM and related protein kinases: safeguarding genome integrity.}, url = {http://dx.doi.org/10.1038/nrc1011}, volume = {3}, year = {2003} }

TY - JOUR ID - citeulike:3333128 L3 - citeulike-article-id:3333128 N2 - Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response--a cornerstone of genome stability--occurs by a swift transduction of the DNA-damage signal to many cellular pathways. A prime example is the cellular response to DNA double-strand breaks, which activate the ATM protein kinase that, in turn, modulates numerous signalling pathways. ATM mutations lead to the cancer-predisposing genetic disorder ataxia-telangiectasia (A-T). Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers. IS - 3 JF - Nature Reviews Cancer SN - 1474-175X AD - The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. yossih@post.tau.ac.il EP - 168 TI - ATM and related protein kinases: safeguarding genome integrity. VL - 3 SP - 155 KW - atm KW - dna_repair KW - review AU - Shiloh, Y PY - 2003/03// UR - http://dx.doi.org/10.1038/nrc1011 ER -