Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Export

@article{citeulike:3333636, abstract = {OBJECTIVE: We examined the potential association between alcohol consumption and genetic polymorphisms in the alcohol metabolizing enzymes, CYP2E1 and ALDH2, in individual susceptibility to breast cancer in a Korean study population. METHODS: Three hundred and forty-six histologically confirmed breast cancer patients and 377 controls with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. The CYP2E1 RsaI polymorphism was determined by a real time PCR method, and the ALDH2 Glu487 Lys polymorphism was determined by a PCR method with confronting two-pair primers (PCR-CTPP). RESULTS: The drinking women had a 1.4-fold risk for breast cancer (95\% CI = 0.99-2.11) compared to never drinkers after adjustment for age and family history of breast cancer. No statistically significant overall differences were seen in the genotype frequencies between breast cancer cases and controls. However, the "ever"-drinking women with the CYP2E1 c2 allele containing genotypes had a 1.9-fold risk (95\% CI = 0.99-3.83) for developing breast cancer compared to non-drinkers with the CYP2E1 c1/c1 genotype (P for interaction = 0.043). CONCLUSION: This study therefore suggests that the CYP2E1 c2 allele may influence the individual susceptibility to breast cancer in alcohol-consuming women.}, address = {Department of Preventive Medicine, General Surgery and Cancer Research Institute, Seoul National University College of Medicine, 27 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea.}, author = {Choi, J. Y. and Abel, J. and Neuhaus, T. and Ko, Y. and Harth, V. and Hamajima, N. and Tajima, K. and Yoo, K. Y. and Park, S. K. and Noh, D. Y. and Han, W. and Choe, K. J. and Ahn, S. H. and Kim, S. U. and Hirvonen, A. and Kang, D.}, citeulike-article-id = {3333636}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/01.fpc.0000054060.98065.fc}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12563175}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12563175}, doi = {10.1097/01.fpc.0000054060.98065.fc}, issn = {0960-314X}, journal = {Pharmacogenetics}, keywords = {alcohol, aldh2, breast, cyp2e1, gxe, korean}, month = {February}, number = {2}, pages = {67--72}, posted-at = {2008-09-24 20:01:21}, priority = {0}, title = {Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.}, url = {http://dx.doi.org/10.1097/01.fpc.0000054060.98065.fc}, volume = {13}, year = {2003} }

TY - JOUR ID - citeulike:3333636 L3 - citeulike-article-id:3333636 N2 - OBJECTIVE: We examined the potential association between alcohol consumption and genetic polymorphisms in the alcohol metabolizing enzymes, CYP2E1 and ALDH2, in individual susceptibility to breast cancer in a Korean study population. METHODS: Three hundred and forty-six histologically confirmed breast cancer patients and 377 controls with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995-2001. The CYP2E1 RsaI polymorphism was determined by a real time PCR method, and the ALDH2 Glu487 Lys polymorphism was determined by a PCR method with confronting two-pair primers (PCR-CTPP). RESULTS: The drinking women had a 1.4-fold risk for breast cancer (95% CI = 0.99-2.11) compared to never drinkers after adjustment for age and family history of breast cancer. No statistically significant overall differences were seen in the genotype frequencies between breast cancer cases and controls. However, the "ever"-drinking women with the CYP2E1 c2 allele containing genotypes had a 1.9-fold risk (95% CI = 0.99-3.83) for developing breast cancer compared to non-drinkers with the CYP2E1 c1/c1 genotype (P for interaction = 0.043). CONCLUSION: This study therefore suggests that the CYP2E1 c2 allele may influence the individual susceptibility to breast cancer in alcohol-consuming women. IS - 2 JF - Pharmacogenetics SN - 0960-314X AD - Department of Preventive Medicine, General Surgery and Cancer Research Institute, Seoul National University College of Medicine, 27 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea. EP - 72 TI - Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. VL - 13 SP - 67 KW - alcohol KW - aldh2 KW - breast KW - cyp2e1 KW - gxe KW - korean AU - Choi, JY AU - Abel, J AU - Neuhaus, T AU - Ko, Y AU - Harth, V AU - Hamajima, N AU - Tajima, K AU - Yoo, KY AU - Park, SK AU - Noh, DY AU - Han, W AU - Choe, KJ AU - Ahn, SH AU - Kim, SU AU - Hirvonen, A AU - Kang, D PY - 2003/02// UR - http://dx.doi.org/10.1097/01.fpc.0000054060.98065.fc ER -