Windows in early mammary development: critical or not? Export

@article{citeulike:3424856, abstract = {Two critical windows in mammary development have been proposed. The first arises from observations in rodents that nutrition during fetal and neonatal periods can affect mammary ductular outgrowth, subsequent proliferative activity and, eventually, tumorigenesis, that is, potentially it could have a long-term effect on pathological outcome (breast cancer) in women. The second similarly involves early diet, but in this case the outcome is phenotypic, in that dairy heifers reared too quickly during the peripubertal period subsequently show impaired udder development and reduced milk yield persisting throughout life. Most mammary development occurs during pregnancy, but this period is usually thought of only in terms of the immediate outcome for the subsequent lactation; it is not believed to be a critical window, at least in terms of lifetime mammary productivity. This review examines the evidence underlying these various claims and attempts to define the mechanisms involved, and also considers whether derangements occurring earlier in life (prenatally) could also have long-term consequences for physiological or pathological mammary development.}, author = {Knight, C. H. and Sorensen, A.}, citeulike-article-id = {3424856}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11597300}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11597300}, issn = {1470-1626}, journal = {Reproduction}, keywords = {benign, breast, etiology, moa, review}, month = {September}, number = {3}, pages = {337--345}, posted-at = {2008-10-17 17:33:08}, priority = {2}, title = {Windows in early mammary development: critical or not?}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11597300}, volume = {122}, year = {2001} }

TY - JOUR ID - citeulike:3424856 L3 - citeulike-article-id:3424856 N2 - Two critical windows in mammary development have been proposed. The first arises from observations in rodents that nutrition during fetal and neonatal periods can affect mammary ductular outgrowth, subsequent proliferative activity and, eventually, tumorigenesis, that is, potentially it could have a long-term effect on pathological outcome (breast cancer) in women. The second similarly involves early diet, but in this case the outcome is phenotypic, in that dairy heifers reared too quickly during the peripubertal period subsequently show impaired udder development and reduced milk yield persisting throughout life. Most mammary development occurs during pregnancy, but this period is usually thought of only in terms of the immediate outcome for the subsequent lactation; it is not believed to be a critical window, at least in terms of lifetime mammary productivity. This review examines the evidence underlying these various claims and attempts to define the mechanisms involved, and also considers whether derangements occurring earlier in life (prenatally) could also have long-term consequences for physiological or pathological mammary development. IS - 3 JF - Reproduction SN - 1470-1626 EP - 345 TI - Windows in early mammary development: critical or not? VL - 122 SP - 337 KW - benign KW - breast KW - etiology KW - moa KW - review AU - Knight, CH AU - Sorensen, A PY - 2001/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/11597300 ER -