Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations Export

@article{citeulike:3768528, abstract = {Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors influencing responsible pharmacokinetic/pharmacogenomic approaches could facilitate the universal application of foreign data and reduce the total amount of phase III clinical trials evaluating risks in different populations. Our objective was to establish and compare genotype (major cytochrome P450 (CYP) enzymes)/phenotype associations for Japanese (native and first- and third-generation Japanese living abroad), Caucasian, Chinese, and Korean populations using a standard drug panel. The mean metabolic ratios (MRs) for the four ethnic groups were similar except for a lower activity of CYP2D6 in Caucasians and CYP2C19 in Asians. Genotype, not ethnicity, impacted the MR for CYP2C9, CYP2C19, and CYP2D6; neither affected CYP1A2, CYP2E1, and CYP3A4/5 activities. We conclude that equivalent plasma drug concentrations and metabolic profiles can be expected for native Japanese, first- and third-generation Japanese, Koreans, and Chinese for compounds handled through these six CYP enzymes.}, author = {Myrand, S. P. and Sekiguchi, K. and Man, M. Z. and Lin, X. and Tzeng, R. Y. and Teng, C. H. and Hee, B. and Garrett, M. and Kikkawa, H. and Lin, C. Y. and Eddy, S. M. and Dostalik, J. and Mount, J. and Azuma, J. and Fujio, Y. and Jang, I. J. and Shin, S. G. and Bleavins, M. R. and Williams, J. A. and Paulauskis, J. D. and Wilner, K. D.}, citeulike-article-id = {3768528}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.clpt.6100482}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/6100482a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18231117}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18231117}, day = {19}, doi = {10.1038/sj.clpt.6100482}, issn = {0009-9236}, journal = {Clinical Pharmacology \& Therapeutics}, keywords = {cyp450, genotype, phenotype, pk, race}, month = {March}, number = {3}, pages = {347--361}, posted-at = {2009-10-28 23:47:50}, priority = {2}, publisher = {Nature Publishing Group}, title = {Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations}, url = {http://dx.doi.org/10.1038/sj.clpt.6100482}, volume = {84}, year = {2008} }

TY - JOUR ID - citeulike:3768528 L3 - citeulike-article-id:3768528 N2 - Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors influencing responsible pharmacokinetic/pharmacogenomic approaches could facilitate the universal application of foreign data and reduce the total amount of phase III clinical trials evaluating risks in different populations. Our objective was to establish and compare genotype (major cytochrome P450 (CYP) enzymes)/phenotype associations for Japanese (native and first- and third-generation Japanese living abroad), Caucasian, Chinese, and Korean populations using a standard drug panel. The mean metabolic ratios (MRs) for the four ethnic groups were similar except for a lower activity of CYP2D6 in Caucasians and CYP2C19 in Asians. Genotype, not ethnicity, impacted the MR for CYP2C9, CYP2C19, and CYP2D6; neither affected CYP1A2, CYP2E1, and CYP3A4/5 activities. We conclude that equivalent plasma drug concentrations and metabolic profiles can be expected for native Japanese, first- and third-generation Japanese, Koreans, and Chinese for compounds handled through these six CYP enzymes. IS - 3 JF - Clinical Pharmacology & Therapeutics SN - 0009-9236 EP - 361 TI - Pharmacokinetics/Genotype Associations for Major Cytochrome P450 Enzymes in Native and First- and Third-generation Japanese Populations: Comparison With Korean, Chinese, and Caucasian Populations PB - Nature Publishing Group VL - 84 SP - 347 KW - cyp450 KW - genotype KW - phenotype KW - pk KW - race AU - Myrand, SP AU - Sekiguchi, K AU - Man, MZ AU - Lin, X AU - Tzeng, RY AU - Teng, CH AU - Hee, B AU - Garrett, M AU - Kikkawa, H AU - Lin, CY AU - Eddy, SM AU - Dostalik, J AU - Mount, J AU - Azuma, J AU - Fujio, Y AU - Jang, IJ AU - Shin, SG AU - Bleavins, MR AU - Williams, JA AU - Paulauskis, JD AU - Wilner, KD PY - 2008/03/19/ UR - http://dx.doi.org/10.1038/sj.clpt.6100482 ER -