MicroRNA involvement in the pathogenesis and management of breast cancer Export

@article{citeulike:4745384, abstract = {MicroRNAs (miRNAs) are a highly abundant class of endogenous small non-coding RNAs (18-25 nucleotides in length) that regulate gene expression by targeting protein-coding mRNAs post-transcriptionally. miRNAs have been implicated in cancer development and progression. As miRNAs and their regulatory functions are further revealed, the more the importance of miRNA-directed gene regulation is emphasised. In the human genome, 695 mature miRNAs have been identified, although computational calculation predicts that this may increase to >1000. Deregulation of miRNA expression profiles is thought to be implicated in the pathogenesis of many human cancers including breast tumours. Breast cancer subtypes are observed to have deranged miRNA expression signatures, which makes miRNAs important targets for developing a novel molecular classification of breast cancer and opening avenues for more individualised treatment strategies for patients with breast cancer. 10.1136/jcp.2008.060681}, author = {Khoshnaw, S. M. and Green, A. R. and Powe, D. G. and Ellis, I. O.}, citeulike-article-id = {4745384}, citeulike-linkout-0 = {http://jcp.bmjjournals.com/cgi/content/reprint/62/5/422}, citeulike-linkout-1 = {http://jcp.bmjjournals.com/cgi/content/full/62/5/422}, citeulike-linkout-2 = {http://dx.doi.org/10.1136/jcp.2008.060681}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19398594}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19398594}, day = {1}, doi = {10.1136/jcp.2008.060681}, issn = {1472-4146}, journal = {J Clin Pathol}, keywords = {breast, mirna, moa, pathology, review}, month = {May}, number = {5}, pages = {422--428}, posted-at = {2009-11-10 05:49:29}, priority = {2}, title = {MicroRNA involvement in the pathogenesis and management of breast cancer}, url = {http://dx.doi.org/10.1136/jcp.2008.060681}, volume = {62}, year = {2009} }

TY - JOUR ID - citeulike:4745384 L3 - citeulike-article-id:4745384 N2 - MicroRNAs (miRNAs) are a highly abundant class of endogenous small non-coding RNAs (18-25 nucleotides in length) that regulate gene expression by targeting protein-coding mRNAs post-transcriptionally. miRNAs have been implicated in cancer development and progression. As miRNAs and their regulatory functions are further revealed, the more the importance of miRNA-directed gene regulation is emphasised. In the human genome, 695 mature miRNAs have been identified, although computational calculation predicts that this may increase to >1000. Deregulation of miRNA expression profiles is thought to be implicated in the pathogenesis of many human cancers including breast tumours. Breast cancer subtypes are observed to have deranged miRNA expression signatures, which makes miRNAs important targets for developing a novel molecular classification of breast cancer and opening avenues for more individualised treatment strategies for patients with breast cancer. 10.1136/jcp.2008.060681 IS - 5 JF - J Clin Pathol SN - 1472-4146 EP - 428 TI - MicroRNA involvement in the pathogenesis and management of breast cancer VL - 62 SP - 422 KW - breast KW - mirna KW - moa KW - pathology KW - review AU - Khoshnaw, SM AU - Green, AR AU - Powe, DG AU - Ellis, IO PY - 2009/05/01/ UR - http://dx.doi.org/10.1136/jcp.2008.060681 ER -