MicroRNA reexpression as differentiation therapy in cancer. Export

@article{citeulike:5636894, abstract = {Since their discovery in the early 2000s, microRNAs (miRNAs) and their penchant for RNA interference have taken the scientific community by storm, working their way into virtually every corner of biological inquiry. The very nature of their action, the ability to simultaneously extinguish the expression of a multitude of genes and negate their functions, immediately suggested therapeutic promise. In this issue of the JCI, a step toward the realization of this promise is described. Taulli et al. demonstrate that the miRNAs miR-1/miR-206, which are routinely lost in advanced, poorly differentiated rhabdomyosarcoma (RMS) but characteristically expressed in the mature skeletal muscle from which these tumors arise, restore the myogenic differentiation program and block the tumorigenic phenotype (see the related article beginning on page 2366). Their data support the notion that these small RNAs, effectively functioning as "micro-sheriffs" by restoring myogenic law and order, hold substantial clinical potential as differentiation therapy for RMS and perhaps other solid tumors. miRNA reexpression therapy constitutes a novel approach to handcuff oncogenes and arrest tumor development.}, author = {Mishra, Prasun J. and Merlino, Glenn}, citeulike-article-id = {5636894}, citeulike-linkout-0 = {http://dx.doi.org/10.1172/JCI40107}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19620782}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19620782}, doi = {10.1172/JCI40107}, issn = {1558-8238}, journal = {The Journal of clinical investigation}, keywords = {chemoprevention, comments, expression, mirna}, month = {August}, number = {8}, pages = {2119--2123}, posted-at = {2009-09-29 17:18:53}, priority = {2}, title = {MicroRNA reexpression as differentiation therapy in cancer.}, url = {http://dx.doi.org/10.1172/JCI40107}, volume = {119}, year = {2009} }

TY - JOUR ID - citeulike:5636894 L3 - citeulike-article-id:5636894 N2 - Since their discovery in the early 2000s, microRNAs (miRNAs) and their penchant for RNA interference have taken the scientific community by storm, working their way into virtually every corner of biological inquiry. The very nature of their action, the ability to simultaneously extinguish the expression of a multitude of genes and negate their functions, immediately suggested therapeutic promise. In this issue of the JCI, a step toward the realization of this promise is described. Taulli et al. demonstrate that the miRNAs miR-1/miR-206, which are routinely lost in advanced, poorly differentiated rhabdomyosarcoma (RMS) but characteristically expressed in the mature skeletal muscle from which these tumors arise, restore the myogenic differentiation program and block the tumorigenic phenotype (see the related article beginning on page 2366). Their data support the notion that these small RNAs, effectively functioning as "micro-sheriffs" by restoring myogenic law and order, hold substantial clinical potential as differentiation therapy for RMS and perhaps other solid tumors. miRNA reexpression therapy constitutes a novel approach to handcuff oncogenes and arrest tumor development. IS - 8 JF - The Journal of clinical investigation SN - 1558-8238 EP - 2123 TI - MicroRNA reexpression as differentiation therapy in cancer. VL - 119 SP - 2119 KW - chemoprevention KW - comments KW - expression KW - mirna AU - Mishra, Prasun AU - Merlino, Glenn PY - 2009/08// UR - http://dx.doi.org/10.1172/JCI40107 ER -