Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Export

@article{citeulike:5779221, abstract = {Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95\% confidence interval (95\% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95\% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95\% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis.}, author = {Stern, Mariana C. and Lin, Jie and Figueroa, Jonine D. and Kelsey, Karl T. and Kiltie, Anne E. and Yuan, Jian-Min M. and Matullo, Giuseppe and Fletcher, Tony and Benhamou, Simone and Taylor, Jack A. and Placidi, Donatella and Zhang, Zuo-Feng F. and Steineck, Gunnar and Rothman, Nathaniel and Kogevinas, Manolis and Silverman, Debra and Malats, Nuria and Chanock, Stephen and Wu, Xifeng and Karagas, Margaret R. and Andrew, Angeline S. and Nelson, Heather H. and Bishop, D. Timothy and Sak, Sei Chung C. and Choudhury, Ananya and Barrett, Jennifer H. and Elliot, Faye and Corral, Rom\'{a}n and Joshi, Amit D. and Gago-Dominguez, Manuela and Cortessis, Victoria K. and Xiang, Yong-Bing B. and Gao, Yu-Tang T. and Vineis, Paolo and Sacerdote, Carlotta and Guarrera, Simonetta and Polidoro, Silvia and Allione, Alessandra and Gurzau, Eugen and Koppova, Kvetoslava and Kumar, Rajiv and Rudnai, Peter and Porru, Stefano and Carta, Angela and Campagna, Marcello and Arici, Cecilia and Park, Sung Shim Lani S. and Garcia-Closas, Montserrat and {International Consortium of Bladder Cancer}}, citeulike-article-id = {5779221}, citeulike-linkout-0 = {http://dx.doi.org/10.1158/0008-5472.CAN-09-1091}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19706757}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19706757}, day = {1}, doi = {10.1158/0008-5472.CAN-09-1091}, issn = {1538-7445}, journal = {Cancer research}, keywords = {bladder, consorcium, environment, genetics}, month = {September}, number = {17}, pages = {6857--6864}, posted-at = {2009-09-13 16:10:45}, priority = {2}, title = {Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer.}, url = {http://dx.doi.org/10.1158/0008-5472.CAN-09-1091}, volume = {69}, year = {2009} }

TY - JOUR ID - citeulike:5779221 L3 - citeulike-article-id:5779221 N2 - Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 studies. Pooled analyses and meta-analyses included 5,282 cases and 5,954 controls of non-Latino white origin. We found evidence for weak but consistent associations with ERCC2 D312N [rs1799793; per-allele odds ratio (OR), 1.10; 95% confidence interval (95% CI), 1.01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044). The association with NBN E185Q was limited to ever smokers (interaction P = 0.002) and was strongest for the highest levels of smoking dose and smoking duration. Overall, our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis. IS - 17 JF - Cancer research SN - 1538-7445 EP - 6864 TI - Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. VL - 69 SP - 6857 KW - bladder KW - consorcium KW - environment KW - genetics AU - Stern, Mariana AU - Lin, Jie AU - Figueroa, Jonine AU - Kelsey, Karl AU - Kiltie, Anne AU - Yuan, Jian-Min AU - Matullo, Giuseppe AU - Fletcher, Tony AU - Benhamou, Simone AU - Taylor, Jack AU - Placidi, Donatella AU - Zhang, Zuo-Feng AU - Steineck, Gunnar AU - Rothman, Nathaniel AU - Kogevinas, Manolis AU - Silverman, Debra AU - Malats, Nuria AU - Chanock, Stephen AU - Wu, Xifeng AU - Karagas, Margaret AU - Andrew, Angeline AU - Nelson, Heather AU - Bishop, Timothy AU - Sak, Sei Chung AU - Choudhury, Ananya AU - Barrett, Jennifer AU - Elliot, Faye AU - Corral, Román AU - Joshi, Amit AU - Gago-Dominguez, Manuela AU - Cortessis, Victoria AU - Xiang, Yong-Bing AU - Gao, Yu-Tang AU - Vineis, Paolo AU - Sacerdote, Carlotta AU - Guarrera, Simonetta AU - Polidoro, Silvia AU - Allione, Alessandra AU - Gurzau, Eugen AU - Koppova, Kvetoslava AU - Kumar, Rajiv AU - Rudnai, Peter AU - Porru, Stefano AU - Carta, Angela AU - Campagna, Marcello AU - Arici, Cecilia AU - Park, Sung Shim Lani AU - Garcia-Closas, Montserrat PY - 2009/09/01/ UR - http://dx.doi.org/10.1158/0008-5472.CAN-09-1091 ER -