Role of Anthracyclines in the Treatment of Early Breast Cancer Export

@article{citeulike:5857226, abstract = {PurposeTo review data relating to anthracyclines in the adjuvant treatment of early breast cancer. DesignThis is a report from a seminar in which the future of anthracyclines in the adjuvant treatment of breast cancer was considered. In particular, the question of whether anthracyclines should now be discarded and replaced by taxanes was addressed. ResultsAccumulating data from large randomized trials indicate that genetic markers may have a role in predicting sensitivity to cytotoxic drugs. However, no reliable, validated test is available for predicting sensitivity to anthracyclines in particular. Topoisomerase II{alpha} amplification and/or deletion, especially in conjunction with human epidermal growth factor receptor-2 amplification, has been proposed to fulfill this role but more data are needed. Currently, only one published trial has shown that a taxane-based regimen may be superior to an anthracycline-based regimen, but several trials indicate that combinations including both anthracyclines and taxanes may be better still. Further studies aimed at optimizing anthracyclines and taxanes in combination, and integrating biologic agents, seem to be the way forward. There is no validated test that can determine whether anthracyclines can be of greater benefit than other agents for individual patients. ConclusionAnthracyclines have been extensively tested in clinical trials spanning several decades; currently, there are insufficient data to recommend replacing them in the adjuvant treatment of breast cancer. 10.1200/JCO.2008.21.4791}, author = {Gianni, Luca and Norton, Larry and Wolmark, Norman and Suter, Thomas M. and Bonadonna, Gianni and Hortobagyi, Gabriel N.}, citeulike-article-id = {5857226}, citeulike-linkout-0 = {http://dx.doi.org/10.1200/JCO.2008.21.4791}, citeulike-linkout-1 = {http://jco.ascopubs.org/content/27/28/4798.abstract}, citeulike-linkout-2 = {http://jco.ascopubs.org/content/27/28/4798.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19687331}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19687331}, day = {1}, doi = {10.1200/JCO.2008.21.4791}, journal = {J Clin Oncol}, keywords = {anthracycline, biomarker, breast, chemotherapy, clinic, genetics, pharmacogenetics, prognosis, review}, month = {October}, number = {28}, pages = {4798--4808}, posted-at = {2009-09-30 04:37:43}, priority = {5}, title = {Role of Anthracyclines in the Treatment of Early Breast Cancer}, url = {http://dx.doi.org/10.1200/JCO.2008.21.4791}, volume = {27}, year = {2009} }

TY - JOUR ID - citeulike:5857226 L3 - citeulike-article-id:5857226 N2 - PurposeTo review data relating to anthracyclines in the adjuvant treatment of early breast cancer. DesignThis is a report from a seminar in which the future of anthracyclines in the adjuvant treatment of breast cancer was considered. In particular, the question of whether anthracyclines should now be discarded and replaced by taxanes was addressed. ResultsAccumulating data from large randomized trials indicate that genetic markers may have a role in predicting sensitivity to cytotoxic drugs. However, no reliable, validated test is available for predicting sensitivity to anthracyclines in particular. Topoisomerase II{alpha} amplification and/or deletion, especially in conjunction with human epidermal growth factor receptor-2 amplification, has been proposed to fulfill this role but more data are needed. Currently, only one published trial has shown that a taxane-based regimen may be superior to an anthracycline-based regimen, but several trials indicate that combinations including both anthracyclines and taxanes may be better still. Further studies aimed at optimizing anthracyclines and taxanes in combination, and integrating biologic agents, seem to be the way forward. There is no validated test that can determine whether anthracyclines can be of greater benefit than other agents for individual patients. ConclusionAnthracyclines have been extensively tested in clinical trials spanning several decades; currently, there are insufficient data to recommend replacing them in the adjuvant treatment of breast cancer. 10.1200/JCO.2008.21.4791 IS - 28 JF - J Clin Oncol EP - 4808 TI - Role of Anthracyclines in the Treatment of Early Breast Cancer VL - 27 SP - 4798 KW - anthracycline KW - biomarker KW - breast KW - chemotherapy KW - clinic KW - genetics KW - pharmacogenetics KW - prognosis KW - review AU - Gianni, Luca AU - Norton, Larry AU - Wolmark, Norman AU - Suter, Thomas AU - Bonadonna, Gianni AU - Hortobagyi, Gabriel PY - 2009/10/01/ UR - http://dx.doi.org/10.1200/JCO.2008.21.4791 ER -