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Nature genetics, Vol. 41, No. 10. (20 October 2009), pp. 1116-1121.
by Rosalind A. Eeles, Zsofia Kote-Jarai, Ali Amin A. Al Olama, et al.Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L. Hopper, Brian E. Henderson, Christopher A. Haiman, Johanna Schleutker, Freddie C. Hamdy, David E. Neal, Jenny L. Donovan, Janet L. Stanford, Elaine A. Ostrander, Sue A. Ingles, Esther M. John, Stephen N. Thibodeau, Daniel Schaid, Jong Y. Park, Amanda Spurdle, Judith Clements, Joanne L. Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R. Rebbeck, Kathleen A. Cooney, Lisa Cannon-Albright, Pierre O. Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong-Wei W. Zhang, Yong-Jie J. Lu, William D. Foulkes, Dallas R. English, Daniel A. Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T. Ardern-Jones, Amanda L. Hall, Lynne T. O'Brien, Rosemary A. Wilkinson, Edward J. Saunders, Elizabeth C. Page, Emma J. Sawyer, Stephen M. Edwards, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Melissa C. Southey, Artitaya Lophatananon, Jo-Fen F. Liu, Laurence N. Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L. Tammela, Anssi Auvinen, Sarah J. Lewis, Angela Cox, Liesel M. FitzGerald, Joseph S. Koopmeiners, Danielle M. Karyadi, Erika M. Kwon, Mariana C. Stern, Roman Corral, Amit D. Joshi, Ahva Shahabi, Shannon K. McDonnell, Thomas A. Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, Frank A. Gardiner, Jyotsna Batra, Mary Anne A. Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M. Ray, Ethan M. Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Douglas F. Easton
Abstract
Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 ...
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Cancer research, Vol. 69, No. 17. (1 September 2009), pp. 6857-6864.
by Mariana C. Stern, Jie Lin, Jonine D. Figueroa, et al.Karl T. Kelsey, Anne E. Kiltie, Jian-Min M. Yuan, Giuseppe Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo-Feng F. Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra Silverman, Nuria Malats, Stephen Chanock, Xifeng Wu, Margaret R. Karagas, Angeline S. Andrew, Heather H. Nelson, D. Timothy Bishop, Sei Chung C. Sak, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Román Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yong-Bing B. Xiang, Yu-Tang T. Gao, Paolo Vineis, Carlotta Sacerdote, Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, Peter Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Lani S. Park, Montserrat Garcia-Closas, International Consortium of Bladder Cancer
Abstract
Tobacco smoking is the most important and well-established bladder cancer risk factor and a rich source of chemical carcinogens and reactive oxygen species that can induce damage to DNA in urothelial cells. Therefore, common variation in DNA repair genes might modify bladder cancer risk. In this study, we present results from meta-analyses and pooled analyses conducted as part of the International Consortium of Bladder Cancer. We included data on 10 single nucleotide polymorphisms corresponding to seven DNA repair genes from 13 ...
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