A minimal and self-consistent in silico cell model based on macromolecular interactions Export

@article{citeulike:4166809, abstract = {10.1098/rstb.2007.2075 A self-consistent minimal cell model with a physically motivated schema for molecular interaction is introduced and described. The genetic and metabolic reaction network of the cell is modelled by multidimensional nonlinear ordinary differential equations, which are derived from biochemical kinetics. The strategy behind this modelling approach is to keep the model sufficiently simple in order to be able to perform studies on evolutionary optimization in populations of cells. At the same time, the model should be complex enough to handle the basic features of genetic control of metabolism and coupling to environmental factors. Thereby, the model system will provide insight into the mechanisms leading to important biological phenomena, such as homeostasis, (circadian) rhythms, robustness and adaptation to a changing environment. One example of modelling a molecular regulatory mechanism, cooperative binding of transcription factors, is discussed in detail.}, author = {Flamm, Christoph and Endler, Lukas and M\"{u}ller, Stefan and Widder, Stefanie and Schuster, Peter}, citeulike-article-id = {4166809}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rstb.2007.2075}, citeulike-linkout-1 = {http://rstb.royalsocietypublishing.org/content/362/1486/1831.abstract}, citeulike-linkout-2 = {http://rstb.royalsocietypublishing.org/content/362/1486/1831.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/17510017}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=17510017}, day = {29}, doi = {10.1098/rstb.2007.2075}, journal = {Philosophical Transactions of the Royal Society B: Biological Sciences}, keywords = {cell, evolution, folding, grn, model, rna}, month = {October}, number = {1486}, pages = {1831--1839}, posted-at = {2009-03-11 23:50:13}, priority = {5}, title = {A minimal and self-consistent in silico cell model based on macromolecular interactions}, url = {http://dx.doi.org/10.1098/rstb.2007.2075}, volume = {362}, year = {2007} }

TY - JOUR ID - citeulike:4166809 L3 - citeulike-article-id:4166809 N2 - 10.1098/rstb.2007.2075 A self-consistent minimal cell model with a physically motivated schema for molecular interaction is introduced and described. The genetic and metabolic reaction network of the cell is modelled by multidimensional nonlinear ordinary differential equations, which are derived from biochemical kinetics. The strategy behind this modelling approach is to keep the model sufficiently simple in order to be able to perform studies on evolutionary optimization in populations of cells. At the same time, the model should be complex enough to handle the basic features of genetic control of metabolism and coupling to environmental factors. Thereby, the model system will provide insight into the mechanisms leading to important biological phenomena, such as homeostasis, (circadian) rhythms, robustness and adaptation to a changing environment. One example of modelling a molecular regulatory mechanism, cooperative binding of transcription factors, is discussed in detail. IS - 1486 JF - Philosophical Transactions of the Royal Society B: Biological Sciences EP - 1839 TI - A minimal and self-consistent in silico cell model based on macromolecular interactions VL - 362 SP - 1831 KW - cell KW - evolution KW - folding KW - grn KW - model KW - rna AU - Flamm, Christoph AU - Endler, Lukas AU - Müller, Stefan AU - Widder, Stefanie AU - Schuster, Peter PY - 2007/10/29/ UR - http://dx.doi.org/10.1098/rstb.2007.2075 ER -