A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation Export

@article{citeulike:4448934, abstract = {During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in cis. Divergence in trans reflected a differential response to the environment and explained the tendency of certain genes to diverge rapidly. Hybrid-specific expression, deviating from the parental range, occurred through novel cis-trans interactions or, more often, through modified trans regulation associated with environmental sensing. These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization. 10.1126/science.1169766}, author = {Tirosh, Itay and Reikhav, Sharon and Levy, Avraham A. and Barkai, Naama}, citeulike-article-id = {4448934}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1169766}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5927/659}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19407207}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19407207}, day = {1}, doi = {10.1126/science.1169766}, journal = {Science}, keywords = {cis-regulation, cis-vs-trans, grn, trans-regulation}, month = {May}, number = {5927}, pages = {659--662}, posted-at = {2009-07-22 12:25:19}, priority = {0}, title = {A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation}, url = {http://dx.doi.org/10.1126/science.1169766}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4448934 L3 - citeulike-article-id:4448934 N2 - During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in cis. Divergence in trans reflected a differential response to the environment and explained the tendency of certain genes to diverge rapidly. Hybrid-specific expression, deviating from the parental range, occurred through novel cis-trans interactions or, more often, through modified trans regulation associated with environmental sensing. These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization. 10.1126/science.1169766 IS - 5927 JF - Science EP - 662 TI - A Yeast Hybrid Provides Insight into the Evolution of Gene Expression Regulation VL - 324 SP - 659 KW - cis-regulation KW - cis-vs-trans KW - grn KW - trans-regulation AU - Tirosh, Itay AU - Reikhav, Sharon AU - Levy, Avraham AU - Barkai, Naama PY - 2009/05/01/ UR - http://dx.doi.org/10.1126/science.1169766 ER -