Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects Export

@article{citeulike:2343648, abstract = {Abstract: We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.}, address = {Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305, Department of Materials Science and Engineering, Stanford University, 476 Lomita Mall, Stanford, California 94305, and Department of Bioengineering, Stanford University School of Medicine, Stanford, California 94305}, author = {Cai, W. and Shin, D. W. and Chen, K. and Gheysens, O. and Cao, Q. and Wang, S. X. and Gambhir, S. S. and Chen, X.}, citeulike-article-id = {2343648}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/nl052405t}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/nl052405t}, day = {12}, doi = {10.1021/nl052405t}, journal = {Nano Lett.}, keywords = {acid-peptide-labeled, alpha-nu-beta3-antagonist, alpha-nu-beta3-integrin, angiogenesis, arginine-glycine-aspartic, atomic-force-microscopy, binding-affinity, ccne-grant, murine-xenograft-model, near-infrared-fluorescence-imaging, nontargeted-qds, quantum-dot, scanning-electron-microscopy, stanford-ccne, targeted-qds}, month = {April}, number = {4}, pages = {669--676}, posted-at = {2008-02-07 16:05:50}, priority = {0}, title = {Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects}, url = {http://dx.doi.org/10.1021/nl052405t}, volume = {6}, year = {2006} }

TY - JOUR ID - citeulike:2343648 L3 - citeulike-article-id:2343648 N2 - Abstract: We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery. IS - 4 JF - Nano Lett. AD - Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University School of Medicine, 1201 Welch Road, Stanford, California 94305, Department of Materials Science and Engineering, Stanford University, 476 Lomita Mall, Stanford, California 94305, and Department of Bioengineering, Stanford University School of Medicine, Stanford, California 94305 EP - 676 TI - Peptide-Labeled Near-Infrared Quantum Dots for Imaging Tumor Vasculature in Living Subjects VL - 6 SP - 669 KW - acid-peptide-labeled KW - alpha-nu-beta3-antagonist KW - alpha-nu-beta3-integrin KW - angiogenesis KW - arginine-glycine-aspartic KW - atomic-force-microscopy KW - binding-affinity KW - ccne-grant KW - murine-xenograft-model KW - near-infrared-fluorescence-imaging KW - nontargeted-qds KW - quantum-dot KW - scanning-electron-microscopy KW - stanford-ccne KW - targeted-qds AU - Cai, W AU - Shin, DW AU - Chen, K AU - Gheysens, O AU - Cao, Q AU - Wang, SX AU - Gambhir, SS AU - Chen, X PY - 2006/04/12/ UR - http://dx.doi.org/10.1021/nl052405t ER -