Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Export

@article{citeulike:3750575, abstract = {10.1073/pnas.0707654105 Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of single-walled carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and detect SWNTs in various organs and tissues of mice over a period of three months. Functionalization of SWNTs by branched polyethylene-glycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in ≈2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. These findings pave the way to future biomedical applications of carbon nanotubes.}, author = {Liu, Zhuang and Davis, Corrine and Cai, Weibo and He, Lina and Chen, Xiaoyuan and Dai, Hongjie}, citeulike-article-id = {3750575}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0707654105}, citeulike-linkout-1 = {http://www.pnas.org/content/105/5/1410.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/5/1410.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18230737}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18230737}, day = {5}, doi = {10.1073/pnas.0707654105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {biodistribution, blood-circulation, carbon-nanotube, ccne-grant, excretion, peg, stanford-ccne, toxicity}, month = {February}, number = {5}, pages = {1410--1415}, posted-at = {2008-12-05 19:28:39}, priority = {2}, title = {Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy}, url = {http://dx.doi.org/10.1073/pnas.0707654105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3750575 L3 - citeulike-article-id:3750575 N2 - 10.1073/pnas.0707654105 Carbon nanotubes are promising new materials for molecular delivery in biological systems. The long-term fate of nanotubes intravenously injected into animals is currently unknown, an issue critical to potential clinical applications of these materials. Here, using the intrinsic Raman spectroscopic signatures of single-walled carbon nanotubes (SWNTs), we measured the blood circulation of intravenously injected SWNTs and detect SWNTs in various organs and tissues of mice over a period of three months. Functionalization of SWNTs by branched polyethylene-glycol (PEG) chains was developed, enabling thus far the longest SWNT blood circulation up to 1 day, relatively low uptake in the reticuloendothelial system (RES), and near-complete clearance from the main organs in ≈2 months. Raman spectroscopy detected SWNT in the intestine, feces, kidney, and bladder of mice, suggesting excretion and clearance of SWNTs from mice via the biliary and renal pathways. No toxic side effect of SWNTs to mice was observed in necropsy, histology, and blood chemistry measurements. These findings pave the way to future biomedical applications of carbon nanotubes. IS - 5 JF - Proceedings of the National Academy of Sciences EP - 1415 TI - Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy VL - 105 SP - 1410 KW - biodistribution KW - blood-circulation KW - carbon-nanotube KW - ccne-grant KW - excretion KW - peg KW - stanford-ccne KW - toxicity AU - Liu, Zhuang AU - Davis, Corrine AU - Cai, Weibo AU - He, Lina AU - Chen, Xiaoyuan AU - Dai, Hongjie PY - 2008/02/05/ UR - http://dx.doi.org/10.1073/pnas.0707654105 ER -