<I>In vitro</I> inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone Export

@article{citeulike:6061345, abstract = {Nanostructured materials are ubiquitous in tissue engineering, drug delivery, and biosensing applications. Nonetheless, little is known about the inflammatory response of materials differing in surface nanoarchitecture. Here we report human monocyte viability and morphology, in addition to inflammatory cytokines (IL-1alpha and B, IL-6, IL-10, IFN-alpha and gamma, TNF-alpha, IL-12, MIP-1alpha and beta), and reactive oxygen species production on several nanostructured surfaces, compared to flat surfaces of the same material. The surfaces studied were titiania nanotubes, short and long silicon oxide, and polycaprolactone nanowires. The results indicate that inflammation on titanium, polycaprolactone, and silicon oxide materials can be reduced by restructuring the surface with nanoarchitecture. Nanostructured surfaces display a reduced inflammation response compared to a respective flat control, with significant differences between titanium and nanotubular titanium. Little difference is observed in the inflammatory response between short and long nanowires of PCL and silicon oxide. All surfaces are significantly less inflammatory than the positive control, lipopolysaccharide. Additionally, we show that flat titanium is more inflammatory than silicon oxide and polycaprolactone. This study shows that nanoarchitecture can be used to reduce the inflammatory response of human monocytes in vitro. {\copyright} 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009}, address = {Laboratory of Therapeutic Micro and Nanotechnology, Department of Physiology, Division of Bioengineering, University of California, San Francisco; San Francisco, California 94158; The Charles Stark Draper Laboratory, Cambridge, Massachusetts 02139; Department of Mechanical Engineering/School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523; Nanosys Inc., 2625 Hanover St., Palo Alto, California 94040; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802; Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802}, author = {Ainslie, Kristy M. and Tao, Sarah L. and Popat, Ketul C. and Daniels, Hugh and Hardev, Veeral and Grimes, Craig A. and Desai, Tejal A.}, citeulike-article-id = {6061345}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jbm.a.32262}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121502480/ABSTRACT}, doi = {10.1002/jbm.a.32262}, issn = {1552-4965}, journal = {Journal of Biomedical Materials Research Part A}, keywords = {cell-viability, polycaprolactone, scanning-electron-microscopy, silicon\_oxide, titania, toxicity}, number = {3}, pages = {647--655}, posted-at = {2009-11-03 19:25:43}, priority = {2}, title = {<I>In vitro</I> inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone}, url = {http://dx.doi.org/10.1002/jbm.a.32262}, volume = {91A}, year = {2009} }

TY - JOUR ID - citeulike:6061345 L3 - citeulike-article-id:6061345 N2 - Nanostructured materials are ubiquitous in tissue engineering, drug delivery, and biosensing applications. Nonetheless, little is known about the inflammatory response of materials differing in surface nanoarchitecture. Here we report human monocyte viability and morphology, in addition to inflammatory cytokines (IL-1alpha and B, IL-6, IL-10, IFN-alpha and gamma, TNF-alpha, IL-12, MIP-1alpha and beta), and reactive oxygen species production on several nanostructured surfaces, compared to flat surfaces of the same material. The surfaces studied were titiania nanotubes, short and long silicon oxide, and polycaprolactone nanowires. The results indicate that inflammation on titanium, polycaprolactone, and silicon oxide materials can be reduced by restructuring the surface with nanoarchitecture. Nanostructured surfaces display a reduced inflammation response compared to a respective flat control, with significant differences between titanium and nanotubular titanium. Little difference is observed in the inflammatory response between short and long nanowires of PCL and silicon oxide. All surfaces are significantly less inflammatory than the positive control, lipopolysaccharide. Additionally, we show that flat titanium is more inflammatory than silicon oxide and polycaprolactone. This study shows that nanoarchitecture can be used to reduce the inflammatory response of human monocytes in vitro. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 IS - 3 JF - Journal of Biomedical Materials Research Part A SN - 1552-4965 AD - Laboratory of Therapeutic Micro and Nanotechnology, Department of Physiology, Division of Bioengineering, University of California, San Francisco; San Francisco, California 94158; The Charles Stark Draper Laboratory, Cambridge, Massachusetts 02139; Department of Mechanical Engineering/School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado 80523; Nanosys Inc., 2625 Hanover St., Palo Alto, California 94040; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802; Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802 EP - 655 TI - <I>In vitro</I> inflammatory response of nanostructured titania, silicon oxide, and polycaprolactone VL - 91A SP - 647 KW - cell-viability KW - polycaprolactone KW - scanning-electron-microscopy KW - silicon_oxide KW - titania KW - toxicity AU - Ainslie, Kristy AU - Tao, Sarah AU - Popat, Ketul AU - Daniels, Hugh AU - Hardev, Veeral AU - Grimes, Craig AU - Desai, Tejal PY - 2009/// UR - http://dx.doi.org/10.1002/jbm.a.32262 ER -