The Kappa-Opiate Receptor Impacts the Pathophysiology and Behavior of Substance Use Export

@article{citeulike:4545304, abstract = {There is increasing evidence that the kappa-opiate receptor, in addition to the mu-opiate receptor, plays an important role in substance use pathophysiology and behavior. As dopamine activity is upregulated through chronic substance use, kappa receptor activity, mediated through the peptide dynorphin, is upregulated in parallel. Dynorphin causes dysphoria and decreased locomotion, and the upregulation of its activity on the kappa receptor likely dampens the excitation caused by increased dopaminergic activity. This feedback mechanism may have significant clinical implications for treating drug dependent patients in various stages of their pathology.}, author = {Mysels, David}, citeulike-article-id = {4545304}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/10550490902925862}, doi = {10.1080/10550490902925862}, journal = {American Journal on Addictions}, keywords = {addiction, neurobiology}, number = {4}, pages = {272--276}, posted-at = {2009-05-19 16:25:42}, priority = {4}, publisher = {Informa Healthcare}, title = {The Kappa-Opiate Receptor Impacts the Pathophysiology and Behavior of Substance Use}, url = {http://dx.doi.org/10.1080/10550490902925862}, volume = {18}, year = {2009} }

TY - JOUR ID - citeulike:4545304 L3 - citeulike-article-id:4545304 N2 - There is increasing evidence that the kappa-opiate receptor, in addition to the mu-opiate receptor, plays an important role in substance use pathophysiology and behavior. As dopamine activity is upregulated through chronic substance use, kappa receptor activity, mediated through the peptide dynorphin, is upregulated in parallel. Dynorphin causes dysphoria and decreased locomotion, and the upregulation of its activity on the kappa receptor likely dampens the excitation caused by increased dopaminergic activity. This feedback mechanism may have significant clinical implications for treating drug dependent patients in various stages of their pathology. IS - 4 JF - American Journal on Addictions EP - 276 TI - The Kappa-Opiate Receptor Impacts the Pathophysiology and Behavior of Substance Use PB - Informa Healthcare VL - 18 SP - 272 KW - addiction KW - neurobiology AU - Mysels, David PY - 2009/// UR - http://dx.doi.org/10.1080/10550490902925862 ER -