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Hotspots of homologous recombination in the human genome: not all homologous sequences are equal

by: James Lupski
Genome Biology, Vol. 5, No. 10. (2004), 242, doi:10.1186/gb-2004-5-10-242  Key: citeulike:11602784

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Abstract

Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.


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