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Effects of Volume Loading and Pressor Agents in Idiopathic Orthostatic Tachycardia

by: Giris Jacob, John R. Shannon, Bonnie Black, Italo Biaggioni, Rogelio Mosqueda-Garcia, Rose M. Robertson, David Robertson
Circulation, Vol. 96, No. 2. (15 July 1997), pp. 575-580, doi:10.1161/01.cir.96.2.575  Key: citeulike:11293430

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Abstract

Background Idiopathic orthostatic tachycardia (IOT) is characterized by an increase in heart rate (HR) with standing of ≥30 bpm that is associated with elevated catecholamine levels and orthostatic symptoms. A dynamic orthostatic hypovolemia and α1-adrenoreceptor hypersensitivity have been demonstrated in IOT patients. There is evidence of an autonomic neuropathy affecting the lower-extremity blood vessels.


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