[Continuous administration of mivacurium for short procedures. Delayed onset and recovery from neuromuscular blockade]

@article{citeulike:240379, abstract = {OBJECTIVE: To assess the delays of onset and spontaneous recovery from neuromuscular block produced by mivacurium administered by continuous infusion for short procedure requiring a deep relaxation. STUDY DESIGN: Prospective open non comparative study. PATIENTS: Twenty-nine class ASA I and II adults undergoing a stomatological procedure of short duration were included in the study. METHOD: General anaesthesia was obtained with a continuous infusion of propofol, supplemented with alfentanil and N2O-O2 mixture. Neuromuscular blockade, assessed with electromyography of the adductor pollicis muscle, was obtained with mivacurium (150 micrograms.kg-1). After restoration of 5\% of neuromuscular transmission, mivacurium was administered by continuous infusion in order to maintain a blockade between 91 and 99\%. RESULTS: The delay for decreasing twitch height by 95\% was 2.9 +/- 1.0 min. The mean dose for maintenance of blockade was 10.9 +/- 1.5 micrograms.kg-1.min-1. The delay of spontaneous recovery from blockade was 10.2 min, 16.6 min and 21.3 min for obtaining 25, 75 and 95\% twitchs respectively. The delay for the twitch increase from 25 to 75\% was 6.6 min. DISCUSSION: Mivacurium in continuous infusion provides rapidly a deep and stable neuromuscular blockade followed by a rapid spontaneous restoration of neuromuscular transmission in patients with normal pseudocholinesterases.}, address = {D\'{e}partement d'Anesth\'{e}sie-R\'{e}animation Chirurgicale, H\^{o}pital Timone Adultes, Marseille.}, author = {Pellissier, D. and Bruder, N. and Mokart, D. and Quilichini, D. and Camatte, S. and Blache, J. L. and François, G. }, citeulike-article-id = {240379}, issn = {0750-7658}, journal = {Ann Fr Anesth Reanim}, number = {6}, pages = {467--471}, posted-at = {2005-06-29 17:21:32}, priority = {2}, title = {[Continuous administration of mivacurium for short procedures. Delayed onset and recovery from neuromuscular blockade]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8745969}, volume = {14}, year = {1995} }

TY - JOUR ID - citeulike:240379 L3 - citeulike-article-id:240379 N2 - OBJECTIVE: To assess the delays of onset and spontaneous recovery from neuromuscular block produced by mivacurium administered by continuous infusion for short procedure requiring a deep relaxation. STUDY DESIGN: Prospective open non comparative study. PATIENTS: Twenty-nine class ASA I and II adults undergoing a stomatological procedure of short duration were included in the study. METHOD: General anaesthesia was obtained with a continuous infusion of propofol, supplemented with alfentanil and N2O-O2 mixture. Neuromuscular blockade, assessed with electromyography of the adductor pollicis muscle, was obtained with mivacurium (150 micrograms.kg-1). After restoration of 5% of neuromuscular transmission, mivacurium was administered by continuous infusion in order to maintain a blockade between 91 and 99%. RESULTS: The delay for decreasing twitch height by 95% was 2.9 +/- 1.0 min. The mean dose for maintenance of blockade was 10.9 +/- 1.5 micrograms.kg-1.min-1. The delay of spontaneous recovery from blockade was 10.2 min, 16.6 min and 21.3 min for obtaining 25, 75 and 95% twitchs respectively. The delay for the twitch increase from 25 to 75% was 6.6 min. DISCUSSION: Mivacurium in continuous infusion provides rapidly a deep and stable neuromuscular blockade followed by a rapid spontaneous restoration of neuromuscular transmission in patients with normal pseudocholinesterases. IS - 6 JF - Ann Fr Anesth Reanim SN - 0750-7658 AD - Département d'Anesthésie-Réanimation Chirurgicale, Hôpital Timone Adultes, Marseille. EP - 471 TI - [Continuous administration of mivacurium for short procedures. Delayed onset and recovery from neuromuscular blockade] VL - 14 SP - 467 AU - Pellissier, D AU - Bruder, N AU - Mokart, D AU - Quilichini, D AU - Camatte, S AU - Blache, JL AU - François, G PY - 1995/// UR - http://view.ncbi.nlm.nih.gov/pubmed/8745969 ER -